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1.发明申请公开(公告)号：US20120141566A1
公开(公告)日：2012-06-07
申请号：US12961634
申请日：2010-12-07
CPC分类号： A01N25/02 , A01N31/08 , A01N43/90 , A01N65/00 , B29B7/42 , B29C47/0004 , B29C47/0009 , B29C47/0021 , B29C47/0026 , B29C47/025 , B29C47/6056 , B29C47/92 , B29C2947/92514 , B29C2947/926 , B29C2947/92704 , B29C2947/92828 , B29C2947/92876 , A01N25/10 , A01N25/12 , A01N25/28 , A01N25/34 , A01N2300/00 , A01N65/20 , A01N65/22 , A01N65/44
摘要： A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.
摘要翻译： 提供了一种形成抗微生物组合物的方法，其包括在熔融共混装置（例如挤出机）内混合抗微生物活性植物油（例如百里酚，香芹酚等）和蛋白质。 尽管通常与熔融加工蛋白质相关的问题，本发明人已经发现可以选择性地控制加工条件和组分以允许形成能够表现出良好机械性能的稳定的熔融加工组合物。 例如，在熔融共混期间使用的挤出温度和剪切速率相对较低，以帮助限制多肽解离，从而最小化聚集和脆化的影响。 虽然使用这种低温/剪切条件往往会降低混合效率，但是本发明人已经发现，可以使用载体流体来提高植物油流入蛋白质的内部结构的能力，其中可以是 保持稳定。 组合物通常也是无水的，通常不含溶剂。 以这种方式，蛋白质在使用前通常不会分散并过早释放植物油。
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2.发明授权公开(公告)号：US08524264B2
公开(公告)日：2013-09-03
申请号：US12961634
申请日：2010-12-07
CPC分类号： A01N25/02 , A01N31/08 , A01N43/90 , A01N65/00 , B29B7/42 , B29C47/0004 , B29C47/0009 , B29C47/0021 , B29C47/0026 , B29C47/025 , B29C47/6056 , B29C47/92 , B29C2947/92514 , B29C2947/926 , B29C2947/92704 , B29C2947/92828 , B29C2947/92876 , A01N25/10 , A01N25/12 , A01N25/28 , A01N25/34 , A01N2300/00 , A01N65/20 , A01N65/22 , A01N65/44
摘要： A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.
摘要翻译： 提供了一种形成抗微生物组合物的方法，其包括在熔融共混装置（例如挤出机）内混合抗微生物活性植物油（例如百里酚，香芹酚等）和蛋白质。 尽管通常与熔融加工蛋白质相关的问题，本发明人已经发现可以选择性地控制加工条件和组分以允许形成能够表现出良好机械性能的稳定的熔融加工组合物。 例如，在熔融共混期间使用的挤出温度和剪切速率相对较低，以帮助限制多肽解离，从而最小化聚集和脆化的影响。 虽然使用这种低温/剪切条件往往会降低混合效率，但是本发明人已经发现，可以使用载体流体来提高植物油流入蛋白质的内部结构的能力，其中可以是 保持稳定。 组合物通常也是无水的，通常不含溶剂。 以这种方式，蛋白质在使用前通常不会分散并过早释放植物油。
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