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公开(公告)号:US09253965B2
公开(公告)日:2016-02-09
申请号:US13434361
申请日:2012-03-29
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
IPC分类号: A01K67/027 , C12N5/06 , C12N15/87 , C07H21/04 , C12N15/85 , C07K16/12 , C07K16/18 , C07K16/46
CPC分类号: C07K16/461 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07H21/04 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/63 , C12N15/8509 , C12N2015/8518 , C12N2800/30 , C12N2800/80
摘要: The invention discloses methods for the generation of chimaeric human-nonhuman antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising the disclosed antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the disclosed methods.
摘要翻译: 本发明公开了产生嵌合人非人抗体和嵌合抗体链,如此产生的抗体和抗体链的方法及其衍生物,包括完全人源化抗体; 包含公开的抗体,抗体链和衍生物的组合物,以及适用于所公开的方法的细胞,非人哺乳动物和载体。
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公开(公告)号:US08591891B2
公开(公告)日:2013-11-26
申请号:US13315027
申请日:2011-12-08
申请人: E-Chiang Lee , Gregory M. Landes , Kyu Chung , Ling Chen , Urvi Desai , David Reed Powell , Seokjoo Hong
发明人: E-Chiang Lee , Gregory M. Landes , Kyu Chung , Ling Chen , Urvi Desai , David Reed Powell , Seokjoo Hong
IPC分类号: A61K39/395 , C07K16/18
CPC分类号: C07K16/22 , A61K2039/505 , C07K14/515 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要: Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译: 提供特异性结合ANGPTL4的单克隆抗体。 提供中和至少一种ANGPTL4活性的单克隆抗体。 提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。
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公开(公告)号:US20120167237A1
公开(公告)日:2012-06-28
申请号:US13416684
申请日:2012-03-09
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Anais Legent , Ian Kirby
IPC分类号: A01K67/027 , C12N5/10 , C12N15/85 , C12N15/13 , C07K16/00
CPC分类号: A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
摘要翻译: 本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链,如此产生的抗体和抗体链的方法及其衍生物,包括完全人源化抗体; 包含适合用于所述方法的所述抗体,抗体链和衍生物的组合物,以及细胞,非人哺乳动物和载体。
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公开(公告)号:US09447177B2
公开(公告)日:2016-09-20
申请号:US13416684
申请日:2012-03-09
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
IPC分类号: A01K67/027 , C07K16/00 , C12N15/85 , C07K16/18 , C07K16/12 , C07K16/46 , A61K39/02 , A61K39/35
CPC分类号: A01K67/0278 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K39/107 , A61K39/35 , A61K2039/505 , C07K16/00 , C07K16/1203 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12N15/8509 , C12N2015/8518
摘要: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
摘要翻译: 本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链,如此制备的抗体和抗体链的方法及其衍生物,包括完全人源化抗体; 包含适合用于所述方法的所述抗体,抗体链和衍生物的组合物,以及细胞,非人哺乳动物和载体。
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公开(公告)号:US09445581B2
公开(公告)日:2016-09-20
申请号:US13433084
申请日:2012-03-28
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Dominik Spensberger , Hui Liu , Jasper Clube
IPC分类号: C12P21/00 , A01K67/027 , C12N5/06 , C12P21/08 , C07K16/46 , C12N15/85 , C07K16/12 , C07K16/18 , C07K16/00
CPC分类号: C07K16/462 , A01K67/0278 , A01K2217/052 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/1239 , C07K16/1282 , C07K16/18 , C07K16/46 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/56 , C07K2317/92 , C12N15/85 , C12N15/8509 , C12N2015/8518
摘要: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising the disclosed antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the disclosed methods.
摘要翻译: 本发明公开了产生嵌合人非 - 人抗体和嵌合抗体链,如此制备的抗体和抗体链的方法及其衍生物,包括完全人源化抗体; 包含所公开的抗体,抗体链和衍生物的组合物,以及适用于所公开的方法的细胞,非人哺乳动物和载体。
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公开(公告)号:US09290566B2
公开(公告)日:2016-03-22
申请号:US13416684
申请日:2012-03-09
申请人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
发明人: Allan Bradley , E-Chiang Lee , Qi Liang , Wei Wang , Glenn Friedrich
摘要: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
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公开(公告)号:US08742075B2
公开(公告)日:2014-06-03
申请号:US13073617
申请日:2011-03-28
申请人: E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
发明人: E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
IPC分类号: C07K16/26 , C07K16/00 , A61K39/395
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要: Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译: 提供特异性结合ANGPTL3的单克隆抗体。 提供中和至少一种ANGPTL3活性的单克隆抗体。 提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。
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公开(公告)号:US20110243948A1
公开(公告)日:2011-10-06
申请号:US13073617
申请日:2011-03-28
申请人: E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
发明人: E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要: Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译: 提供特异性结合ANGPTL3的单克隆抗体。 提供中和至少一种ANGPTL3活性的单克隆抗体。 提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。
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公开(公告)号:US07655762B2
公开(公告)日:2010-02-02
申请号:US11327844
申请日:2006-01-06
申请人: E-Chiang Lee , Gregory M. Landes , Kyu Chung , Ling Chen , Urvi Desai , David Reed Powell , Seokjoo Hong
发明人: E-Chiang Lee , Gregory M. Landes , Kyu Chung , Ling Chen , Urvi Desai , David Reed Powell , Seokjoo Hong
IPC分类号: C07K16/18
CPC分类号: C07K16/22 , A61K2039/505 , C07K14/515 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要: Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译: 提供特异性结合ANGPTL4的单克隆抗体。 提供中和至少一种ANGPTL4活性的单克隆抗体。 提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。
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公开(公告)号:US20060222645A1
公开(公告)日:2006-10-05
申请号:US11327844
申请日:2006-01-06
申请人: E-Chiang Lee , Gregory Landes , Kyu Chung , Ling Chen , Urvi Desai , David Powell , Seokjoo Hong
发明人: E-Chiang Lee , Gregory Landes , Kyu Chung , Ling Chen , Urvi Desai , David Powell , Seokjoo Hong
IPC分类号: A61K39/395 , C07K16/22
CPC分类号: C07K16/22 , A61K2039/505 , C07K14/515 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要: Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
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