公开(公告)号：US20090196930A1

公开(公告)日：2009-08-06

申请号：US12343920

申请日：2008-12-24

申请人： Mark W. Surber ,  Gary T. Elliott ,  Geoffrey Eugene Barker

发明人： Mark W. Surber ,  Gary T. Elliott ,  Geoffrey Eugene Barker

IPC分类号： A61K9/14 ,  A61K33/00 ,  A61P11/00 ,  A61M15/00

CPC分类号： A61K33/00 ,  A61K9/0043 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008

摘要： Disclosed herein are formulations of nitrite, nitrite salt, or nitrite- or nitric oxide-producing compounds suitable for aerosolization and use of such formulations for aerosol administration of nitrite, nitrite salt, or nitrite- or nitric oxide-donating compounds for the treatment of pulmonary arterial hypertension, intra-nasal or pulmonary bacterial infections, or to treat or prevent ischemic reperfusion injury of the heart, brain and organs involved in transplantation. In particular, inhaled nitrite, nitrite salt, or nitrite- or nitric oxide-donating compound specifically formulated and delivered to the respiratory tract for the indications is described. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures and manufacturing processes for production and use of the compositions described.

摘要翻译： 本文公开了适用于气溶胶化的亚硝酸盐，亚硝酸盐或产生亚硝酸盐或一氧化一氮的化合物的制剂，并且用于这种制剂用于气雾剂施用亚硝酸盐，亚硝酸盐或用于治疗肺的亚硝酸盐或一氧化氮的化合物 动脉高血压，鼻内或肺部细菌感染，或治疗或预防参与移植的心脏，脑和器官的缺血再灌注损伤。 特别地，描述了特别配制并输送到呼吸道用于适应症的吸入亚硝酸盐，亚硝酸盐或亚硝酸盐或一氧化氮供体化合物。 组合物包括本文所述的所有制剂，试剂盒和装置组合。 方法包括用于生产和使用所述组合物的吸入程序和制造方法。