公开(公告)号：US20110152362A1

公开(公告)日：2011-06-23

申请号：US11940710

申请日：2007-11-15

申请人： Yong Moon CHOI ,  Robert Gordon ,  Gerald P. Novak ,  Carlos R. Plata-Salaman ,  Roy E. Twyman ,  H. Steve White ,  Boyu Zhao

发明人： Yong Moon CHOI ,  Robert Gordon ,  Gerald P. Novak ,  Carlos R. Plata-Salaman ,  Roy E. Twyman ,  H. Steve White ,  Boyu Zhao

IPC分类号： A61K31/27 ,  A61P25/08

CPC分类号： A61K45/06 ,  A61K31/27 ,  A61K31/325 ,  A61K2300/00

摘要： This invention is directed to methods for preventing, treating, reversing, inhibiting or arresting epilepsy and epileptogenesis in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof: wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).

摘要翻译： 本发明涉及在受试者中预防，治疗，逆转，抑制或阻止癫痫和癫痫发生的方法，其包括向有需要的受试者施用治疗有效量的选自式（I）和式 II）或其药学上可接受的盐或酯：其中苯基在X上被一至五个选自氟，氯，溴和碘的卤素原子取代; 并且，R 1，R 2，R 3，R 4，R 5和R 6独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。