公开(公告)号：US06689319B1

公开(公告)日：2004-02-10

申请号：US09429895

申请日：1999-10-29

申请人： William D. Fisher ,  Henrique A. S. Martins ,  Peter G. Webb

发明人： William D. Fisher ,  Henrique A. S. Martins ,  Peter G. Webb

IPC分类号： G01N3510

CPC分类号： B41J29/393 ,  B01J19/0046 ,  B01J2219/00351 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N21/95607

摘要： An apparatus and method are provided for producing and inspecting a plurality of deposited features in a pattern on a portion of a substrate surface, as in an oligonucleotide array. The apparatus comprises a printhead for depositing a fluid to form the array of features on the substrate surface and a camera for imaging the deposited features. The apparatus also comprises a printhead controller for positioning and activating the inkjet printhead to deposit the array features. The camera, e.g., a digital line scan camera, is controlled by a camera controller such that the camera acquires images corresponding to substantially only the portion of the surface on which features should have been deposited. The camera and printhead are preferably situated such that an induced movement of the printhead relative to the substrate results in a substantially identical corresponding movement of the camera. Optionally, the apparatus further comprises means for comparing an image acquired by the camera with a predetermined standard to produce a signal.

摘要翻译： 提供了一种用于在衬底表面的一部分上以图案形式生产和检查多个沉积特征的装置和方法，如寡核苷酸阵列中那样。 该装置包括用于沉积流体以形成衬底表面上的特征阵列的打印头和用于对沉积的特征进行成像的照相机。 该装置还包括用于定位和启动喷墨打印头以沉积阵列特征的打印头控制器。 照相机，例如数字线扫描照相机，由照相机控制器控制，使得照相机获取对应于基本上只有特征应该已经被沉积的表面部分的图像。 相机和打印头优选地被定位成使得打印头相对于基板的感应运动导致相机的基本上相同的相应运动。 可选地，该装置还包括用于将由照相机获取的图像与预定标准进行比较以产生信号的装置。