专利检索 ap:"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE SCIENTIFIQUE MEDICALE (INSERM)" 第 1 页

1.

发明授权
Identification of a JAK2 mutation in polycythemia vera 有权

公开(公告)号：US10364430B2

公开(公告)日：2019-07-30

申请号：US14164880

申请日：2014-01-27

申请人： Institut Gustave-Roussy , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE SCIENTIFIQUE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS , UNIVERSITE DE VERSAILLES—ST QUENTIN EN YVELINES , UNIVERSITE PARIS-SUD

发明人： William Vainchenker , Valerie Ugo , Chloe James , Jean-Pierre Le Couedic , Nicole Casadevall

IPC分类号： C12N9/12 , C12N15/113 , C12Q1/6813 , C12Q1/6883 , G01N33/574

摘要： The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.