公开(公告)号：US20110274930A1

公开(公告)日：2011-11-10

申请号：US13142876

申请日：2010-03-02

申请人： KwangMeyung Kim ,  Iek Chan Kwon ,  Kui Won Choi ,  Seung Young Lee ,  In Chan Youn ,  Myung Sook Huh ,  So Jin Lee

发明人： KwangMeyung Kim ,  Iek Chan Kwon ,  Kui Won Choi ,  Seung Young Lee ,  In Chan Youn ,  Myung Sook Huh ,  So Jin Lee

IPC分类号： C07H21/02 ,  B32B5/16 ,  C08G73/04

CPC分类号： C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/51 ,  C12N2320/32 ,  C12N2320/51

摘要： The present invention relates to a high-molecular weight oligonucleotides polymerization method which increases in vivo stability, and to the use of a high-molecular weight oligonucleotides prepared by the polymerization method.The oligonucleotide polymerization method of the present invention is advantageous in that an oligonucleotide with a small molecular weight can be easily polymerized into high-molecular weight oligonucleotides. Further, the high-molecular oligonucleotide prepared by the method of the present invention can bind to hydrophilic high-molecular materials or inorganic materials, and then can be stably delivered to a living body. Therefore, the high-molecular oligonucleotide prepared by the method of the present invention can be widely used for treating various diseases.

摘要翻译： 本发明涉及增加体内稳定性的高分子量寡核苷酸聚合方法以及通过聚合方法制备的高分子量寡核苷酸的用途。 本发明的寡聚体聚合方法的优点在于，可以容易地将分子量小的寡核苷酸聚合成高分子量寡核苷酸。 此外，通过本发明的方法制备的高分子量寡核苷酸可以结合亲水性高分子材料或无机材料，然后可以稳定地递送到生物体。 因此，通过本发明的方法制备的高分子寡核苷酸可广泛用于治疗各种疾病。