公开(公告)号：US4126615A

公开(公告)日：1978-11-21

申请号：US748221

申请日：1976-12-07

申请人： Istvan Turcsan ,  Istvan Jelinek ,  Jozsef Ugrics ,  Istvan Csik ,  Eva Somfai ,  Iren Csaszar nee Toth

发明人： Istvan Turcsan ,  Istvan Jelinek ,  Jozsef Ugrics ,  Istvan Csik ,  Eva Somfai ,  Iren Csaszar nee Toth

IPC分类号： C07C51/08 ,  C07D217/20

CPC分类号： C07D217/20 ,  C07C51/08

摘要： In the production of perparine or papaverine and their hydrochlorides, the formation of impurities in the reaction mixture is suppressed by fractionating a 3,4-di-R-benzyl-cyanide in the presence of an organic base (e.g. pyridine, dimethylformamide, ethylenediamine or triethylamine) followed by hydrogenation with a Raney-nickel catalyst treated with aqueous ammonium carbonate solution. R is methoxy or ethoxy.