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公开(公告)号：US20080146500A1
公开(公告)日：2008-06-19
申请号：US11573830
申请日：2005-08-11
申请人： Bengt Krister Bokvist , John Philip Mayer , Lianshan Zhang , Jorge Alsina-Fernandez , Andrew Mark Vick
发明人： Bengt Krister Bokvist , John Philip Mayer , Lianshan Zhang , Jorge Alsina-Fernandez , Andrew Mark Vick
CPC分类号： A61K47/60
摘要： The present invention encompasses peptides that selectively activate the VPAC2 receptor and are useful in the treatment of diabetes.
摘要翻译： 本发明包括选择性活化VPAC2受体并可用于治疗糖尿病的肽。
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公开(公告)号：US5929032A
公开(公告)日：1999-07-27
申请号：US761038
申请日：1996-12-05
申请人： Josette Fran.cedilla.oise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
发明人： Josette Fran.cedilla.oise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
IPC分类号： C12N15/09 , A61K38/00 , A61P1/00 , A61P11/00 , A61P25/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12R1/91 , A61K38/18
CPC分类号： C07K14/4756 , C07K14/4705 , A61K38/00
摘要： The survival and proliferation of Schwann cells can be promoted by culturing such cells in the presence of peptides derived from the EGF-like domain of proteins from the NDF/heregulin family. Colon epithelial cells can be stimulated to multiply and differentiate by culturing such cells in the presence of the same peptides.
摘要翻译： 通过在衍生自NDF / asgulin家族的蛋白质的EGF样结构域的肽存在下培养这样的细胞可以促进雪旺氏细胞的存活和增殖。 可以通过在相同的肽存在下培养这样的细胞来刺激结肠上皮细胞繁殖和分化。
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公开(公告)号：US5849705A
公开(公告)日：1998-12-15
申请号：US761762
申请日：1996-12-05
IPC分类号： C12N15/09 , A61K38/00 , A61P1/00 , A61P11/00 , A61P25/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12R1/91 , A61K38/18
CPC分类号： C07K14/4756 , C07K14/4705 , A61K38/00
摘要： Schwann cells can be treated in vivo to survive longer and to proliferate by contacting them with peptides derived from the EGF-like domain of proteins of the NDF/heregulin family.
摘要翻译： 可以在体内处理雪旺氏细胞以更长时间地存活并通过与来自NDF / asgulin家族的蛋白质的EGF样结构域的肽接触而增殖。
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公开(公告)号：US08183340B2
公开(公告)日：2012-05-22
申请号：US11913365
申请日：2006-05-11
申请人： Wolfgang Glaesner , John Philip Mayer , Rohn Lee Millican, Jr. , Andrew Mark Vick , Lianshan Zhang
发明人： Wolfgang Glaesner , John Philip Mayer , Rohn Lee Millican, Jr. , Andrew Mark Vick , Lianshan Zhang
IPC分类号： A61K38/26 , C07K14/605 , A61P3/10
CPC分类号： C07K14/605 , A61K47/60
摘要： The invention provides GLP-1 compounds coupled to two polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating conditions or disorders benefited by lowering blood glucose, decreasing food intake, decreasing gastric or intestinal emptying, increasing beta (β) cell population, or decreasing gastric or intestinal motility.
摘要翻译： 本发明提供了与两个聚乙二醇分子或其衍生物偶联的GLP-1化合物，当与未PEG化肽相比时，产生具有延长的半衰期和较慢清除率的生物活性肽。 这些聚乙二醇化GLP-1化合物和组合物可用于治疗通过降低血糖，减少食物摄取，减少胃或肠排空，增加β（β）细胞群体或减少胃或肠运动而受益的病症或病症。
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公开(公告)号：US20090118167A1
公开(公告)日：2009-05-07
申请号：US11573917
申请日：2005-08-11
申请人： Bengt Krister Bokvist , John Philip Mayer , Lianshan Zhang , Jorge Alsina-Fernandez , Andrew Mark Vick
发明人： Bengt Krister Bokvist , John Philip Mayer , Lianshan Zhang , Jorge Alsina-Fernandez , Andrew Mark Vick
IPC分类号： A61K38/17 , C07K14/475
CPC分类号： A61K47/60
摘要： The invention provides VPAC2R peptide agonists coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide.
摘要翻译： 本发明提供了与至少一种聚乙二醇分子或其衍生物偶联的VPAC2R肽激动剂，当与未PEG化肽相比时，产生具有延长的半衰期和较慢清除率的生物活性肽。
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公开(公告)号：US20110237503A1
公开(公告)日：2011-09-29
申请号：US13069425
申请日：2011-03-23
IPC分类号： A61K38/22 , C07K14/575 , A61P3/04 , A61P3/10
CPC分类号： C07K14/605 , A61K38/00 , C07K14/723
摘要： The present invention is in the field of treatment of diabetes and relates to peptides that exhibit activity for both glucose-dependent insulinotropic peptide receptor (GIP-R) and glucagon-like peptide-1 receptor (GLP-1-R) and are selective over glucagon receptor (Gluc-R). Specifically provided are GIP analogs with amino acid substitutions introduced to modulate activity for both GIP-R and GLP-1-R and maintain selectivity over Gluc-R.
摘要翻译： 本发明涉及糖尿病治疗领域，涉及对葡萄糖依赖性促胰岛素肽受体（GIP-R）和胰高血糖素样肽-1受体（GLP-1-R）具有活性的肽，其选择性 胰高血糖素受体（Gluc-R）。 具体提供的是具有引入氨基酸取代的GIP类似物以调节GIP-R和GLP-1-R的活性并保持对Gluc-R的选择性。
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公开(公告)号：US07291619B2
公开(公告)日：2007-11-06
申请号：US10466121
申请日：2002-01-23
申请人： Christopher Kelly Biggers , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Larry Wayne Hertel , Vincent Mancuso , Michael John Martinelli , John Philip Mayer , Paul Leslie Ornstein , Timothy Ivo Richardson , Jikesh Arvind Shah , Qing Shi , Zhipei Wu , Chaoyu Xie
发明人： Christopher Kelly Biggers , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Larry Wayne Hertel , Vincent Mancuso , Michael John Martinelli , John Philip Mayer , Paul Leslie Ornstein , Timothy Ivo Richardson , Jikesh Arvind Shah , Qing Shi , Zhipei Wu , Chaoyu Xie
IPC分类号： A61K31/496 , C07D217/26 , C07D209/44
CPC分类号： A61K45/06 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to melanocortin receptor agonists of formula (I), which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式（I）的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍
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公开(公告)号：US5686415A
公开(公告)日：1997-11-11
申请号：US760815
申请日：1996-12-05
申请人： Josette Fran.cedilla.oise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
发明人： Josette Fran.cedilla.oise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
IPC分类号： C12N15/09 , A61K38/00 , A61P1/00 , A61P11/00 , A61P25/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12R1/91 , C07K13/00 , C12N15/12 , A61K37/02
CPC分类号： C07K14/4756 , C07K14/4705 , A61K38/00
摘要： Colon epithelial cells are stimulated to multiply, grow and mature by contacting them in vivo with peptides derived from the EGF-like domain of proteins of the NDF/heregulin family.
摘要翻译： 通过将其体内接触来源于NDF / asgulin家族的蛋白质的EGF样结构域的肽，刺激结肠上皮细胞繁殖，生长和成熟。
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公开(公告)号：US08815811B2
公开(公告)日：2014-08-26
申请号：US13069425
申请日：2011-03-23
IPC分类号： A61K38/16 , A61P3/10 , C07K14/00 , C07K14/595 , C07K14/605 , C07K14/72 , A61K38/00
CPC分类号： C07K14/605 , A61K38/00 , C07K14/723
摘要： The present invention is in the field of treatment of diabetes and relates to peptides that exhibit activity for both glucose-dependent insulinotropic peptide receptor (GIP-R) and glucagon-like peptide-1 receptor (GLP-1-R) and are selective over glucagon receptor (Gluc-R). Specifically provided are GIP analogs with amino acid substitutions introduced to modulate activity for both GIP-R and GLP-1-R and maintain selectivity over Gluc-R.
摘要翻译： 本发明涉及糖尿病治疗领域，涉及对葡萄糖依赖性促胰岛素肽受体（GIP-R）和胰高血糖素样肽-1受体（GLP-1-R）具有活性的肽，其选择性 胰高血糖素受体（Gluc-R）。 具体提供的是具有氨基酸取代的GIP类似物，用于调节GIP-R和GLP-1-R的活性并保持对Gluc-R的选择性。
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公开(公告)号：US20090215981A1
公开(公告)日：2009-08-27
申请号：US11913365
申请日：2006-05-11
申请人： Wolfgang Glaesner , John Philip Mayer , Rohn Lee Millican, JR. , Andrew Mark Vick , Lianshan Zhang
发明人： Wolfgang Glaesner , John Philip Mayer , Rohn Lee Millican, JR. , Andrew Mark Vick , Lianshan Zhang
IPC分类号： C07K14/605 , A61K38/26 , A61P3/04 , A61P3/10
CPC分类号： C07K14/605 , A61K47/60
摘要： The invention provides GLP-1 compounds coupled to two polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating conditions or disorders benefited by lowering blood glucose, decreasing food intake, decreasing gastric or intestinal emptying, increasing beta (β) cell population, or decreasing gastric or intestinal motility.
摘要翻译： 本发明提供了与两个聚乙二醇分子或其衍生物偶联的GLP-1化合物，当与未PEG化肽相比时，产生具有延长的半衰期和较慢清除率的生物活性肽。 这些聚乙二醇化GLP-1化合物和组合物可用于治疗通过降低血糖，减少食物摄入，减少胃或肠排空，增加β（β）细胞群体或减少胃或肠蠕动而受益的病症或障碍。
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