公开(公告)号：US20060147434A1

公开(公告)日：2006-07-06

申请号：US10542104

申请日：2004-01-16

申请人： Kazumasa Ogasawara ,  Kaiichi Kajino ,  Ichiro Nakamura ,  Keiichi Kontani

发明人： Kazumasa Ogasawara ,  Kaiichi Kajino ,  Ichiro Nakamura ,  Keiichi Kontani

IPC分类号： A61K48/00 ,  C12N5/08

CPC分类号： C12N5/064 ,  A61K35/12 ,  A61K35/28 ,  A61K2035/122 ,  A61K2035/124 ,  A61K2039/515 ,  C12N5/0639

摘要： It is intended to provide expired dendritic cells having characteristics of the following (E1) to (E3): (E1) not shifting into a mature type due to an action of a natural immune stimulant or a permanent immune potentiator;(E2) having the same shape as immature DC; and (E3) expressing IL-10. It is intended to provide Permanently activated dendritic cells having the following characteristics:(M2-1) having projecting dendrites and forming aggregation clusters;(M2-2) being capable of activating unreacted cytotoxic T cells (CTL);(M2-3) having stable properties under the action of anti-CD40 monoclonal antibody; and (M2-4) showing a high expression level of at least one member selected from the group consisting of CD80, CD83 and CD86.

摘要翻译： 旨在提供具有以下（E1）至（E3）特征的终止的树突状细胞：（E1）由于天然免疫刺激剂或永久免疫增强剂的作用而不转化成成熟型;（E2）具有 与未成熟DC相同的形状; 和（E3）表达IL-10。 旨在提供具有以下特征的永久活化的树突细胞：（M2-1）具有突出的树突并形成聚集簇;（M2-2）能够活化未反应的细胞毒性T细胞（CTL）;（M2-3）具有 抗CD40单克隆抗体作用下的稳定性; 和（M2-4）表示选自CD80，CD83和CD86中的至少一种成员的高表达水平。