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    Modulators of protein tyrosine phosphatases (PTPases)
    1.
    发明授权
    Modulators of protein tyrosine phosphatases (PTPases) 失效
    蛋白酪氨酸磷酸酶（PTPases）的调节剂

    公开(公告)号：US06225329B1

    公开(公告)日：2001-05-01

    申请号：US09265069

    申请日：1999-03-09

    申请人： Lutz Stefan Richter ,  Henrik Sune Andersen ,  Josef Vagner ,  Claus Bekker Jeppesen ,  Niels Peter Hundahl Møller ,  Sven Branner ,  Jing Su ,  Farid Bakir ,  Luke Milburn Judge

    发明人： Lutz Stefan Richter ,  Henrik Sune Andersen ,  Josef Vagner ,  Claus Bekker Jeppesen ,  Niels Peter Hundahl Møller ,  Sven Branner ,  Jing Su ,  Farid Bakir ,  Luke Milburn Judge

    IPC分类号： A61K3141

    CPC分类号： C07D213/79 ,  C07D213/80 ,  C07D239/557 ,  C07D241/26 ,  C07D261/08 ,  C07D271/07

    摘要： The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTP&agr;, LAR and HePTP or the like, wherein A, R1, R2, R3, R4, R16 and R17 are as defined in the specification. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

    摘要翻译： 本发明提供新的式1化合物，含有这些化合物的组合物，其使用方法及其制备方法，其中这些化合物是蛋白酪氨酸磷酸酶（PTPase）如PTP1B，CD45，SHP-1， SHP-2，PTPalpha，LAR和HePTP等，其中A，R1，R2，R3，R4，R16和R17如说明书中所定义。 该化合物可用于治疗I型糖尿病，II型糖尿病，葡萄糖耐量降低，胰岛素抵抗，肥胖症，免疫功能障碍，包括凝血系统功能障碍的自身免疫性疾病，包括哮喘，过度性疾病，骨质疏松症，包括癌症和牛皮癣在内的增殖性疾病 ，具有减少或增加的生长激素合成或作用的疾病，调节生长激素释放/或对生长激素的反应，包括阿尔茨海默氏病和精神分裂症的疾病以及传染病的激素或细胞因子合成减少或增加的疾病。