公开(公告)号：US20150361498A1

公开(公告)日：2015-12-17

申请号：US14764448

申请日：2014-01-29

Applicant: Yuan-Tsong CHEN ,  Andrew Tai-Ann CHENG ,  Chien-Hsium CHEN ,  Chau-Shoun LEE ,  Ming Ta Michael LEE ,  ACADEMIA SINICA

Inventor： Andrew Tai-Ann Cheng ,  Yuan-Tsong Chen ,  Chien-Hsiun Chen ,  Chau-Shoun Lee ,  Ming Ta Michael Lee

IPC: C12Q1/68 ,  A61K33/00

CPC classification number: C12Q1/6883 ,  A61K33/00 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: Described herein is a method of determining lithium responsiveness in a bipolar disorder patient. The method includes obtaining a sample from a patient having bipolar disorder, and assaying the sample for the presence or absence of one or more glutamate decarboxylase-like 1 (GADL1) gene variants selected from the group consisting of a T allele of the single nucleotide polymorphism (SNP) rs17026688, a G allele of the SNP rs17026651, and GADL1 1VS8+48delG. The presence of one or more of the GADL1 gene variants indicates that the patient is responsive to lithium treatment.

Abstract translation: 本文描述了在双相障碍患者中测定锂响应性的方法。 该方法包括从患有双相性精神障碍的患者获得样品，并且测定样品中是否存在一种或多种选自单核苷酸多态性的T等位基因的谷氨酸脱羧酶样1（GADL1）基因变体 （SNP）rs17026688，SNP rs17026651的G等位基因和GADL1 1VS8 + 48delG。 一种或多种GADL1基因变体的存在表明患者对锂处理有反应。