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公开(公告)号：US08577624B2
公开(公告)日：2013-11-05
申请号：US12747598
申请日：2008-12-12
CPC分类号： C12N9/14 , C07K2299/00 , C12Y306/01003
摘要： The present invention relates to a crystal structure of a plasma membrane proton pump type ATPase. The invention further describes method for identification of modulators of ATPases as well as uses of such modulators. Based on the provided three dimensional structure of the ATPase, various method, such as computer implemented methods may be used for identification of modulators, such putative modulators may be further analysed using in vitro and in vivo experiments to confirm there functionality. Several modulator interaction regions are described as target of regulation by ATPase modulators.
摘要翻译： 本发明涉及质膜质子泵型ATP酶的晶体结构。 本发明还描述了鉴定ATP酶的调节剂的方法以及这种调节剂的用途。 基于提供的ATP酶的三维结构，可以使用各种方法，例如计算机实施的方法来鉴定调节剂，可以使用体外和体内实验进一步分析这些推定的调节剂以确认其功能。 多个调节剂相互作用区域被描述为通过ATP酶调节剂调节的靶标。
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公开(公告)号：US20100296963A1
公开(公告)日：2010-11-25
申请号：US12747598
申请日：2008-12-12
IPC分类号： C22C5/04 , C12N9/14 , C40B30/02 , C12Q1/34 , G06G7/58 , G06G7/48 , C22B11/00 , C22B59/00 , C22C28/00
CPC分类号： C12N9/14 , C07K2299/00 , C12Y306/01003
摘要： The present invention relates to a crystal structure of a plasma membrane proton pump type ATPase. The invention further describes method for identification of modulators of ATPases as well as uses of such modulators. Based on the provided three dimensional structure of the ATPase, various method, such as computer implemented methods may be used for identification of modulators, such putative modulators may be further analysed using in vitro and in vivo experiments to confirm there functionality. Several modulator interaction regions are described as target of regulation by ATPase modulators.
摘要翻译： 本发明涉及质膜质子泵型ATP酶的晶体结构。 本发明还描述了鉴定ATP酶的调节剂的方法以及这种调节剂的用途。 基于提供的ATP酶的三维结构，可以使用各种方法，例如计算机实施的方法来鉴定调节剂，可以使用体外和体内实验进一步分析这些推定的调节剂以确认其功能。 多个调节剂相互作用区域被描述为通过ATP酶调节剂调节的靶标。
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