公开(公告)号：US06420606B1

公开(公告)日：2002-07-16

申请号：US09602772

申请日：2000-06-23

Applicant: Mohammad Aslam ,  Patrick MacManus ,  Margaret Cullen

Inventor： Mohammad Aslam ,  Patrick MacManus ,  Margaret Cullen

IPC: C07C21100

CPC classification number: C07C213/06 ,  C07C217/76

Abstract: Disclosed are methods of producing of alkoxy arylamine compounds which find particular use in the syntheses of pharmaceutical drug. The alkoxy arylamine compounds generally have the formula: H2N—Ar—OR wherein Ar is an unsubstituted or substituted aromatic group, and R is an unsubstituted or substituted alkyl or aryl group. The methods comprise generally, the steps of (a) alkylating a protected-amino arylalcohol to form a protected-amino arylether; and (b) deprotecting said protected-amino arylether to form an alkoxy arylamine compound.

Abstract translation: 公开了在药物合成中特别有用的烷氧基芳基胺化合物的制备方法。 烷氧基芳基胺化合物通常具有下式：其中Ar是未取代或取代的芳基，R是未取代或取代的烷基或芳基。 方法通常包括以下步骤：（a）将保护的氨基芳基醇烷基化以形成被保护的氨基芳基醚; 和（b）使所述保护氨基芳基醚脱保护形成烷氧基芳基胺化合物。