公开(公告)号：US09611235B2

公开(公告)日：2017-04-04

申请号：US13102475

申请日：2011-05-06

申请人： Xiao-kun Zhang ,  Ying Su ,  Hu Zhou ,  Wen Liu ,  Pei-Qiang Huang

发明人： Xiao-kun Zhang ,  Ying Su ,  Hu Zhou ,  Wen Liu ,  Pei-Qiang Huang

IPC分类号： C07D295/112 ,  A61K38/19 ,  C07C57/62 ,  C07C59/72 ,  C07C255/57 ,  C07D213/55 ,  G01N33/50

CPC分类号： C07D295/112 ,  A61K38/191 ,  C07C57/62 ,  C07C59/72 ,  C07C255/57 ,  C07D213/55 ,  G01N33/5011 ,  G01N2333/70567 ,  G01N2510/00

摘要： Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenvironment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.

公开(公告)号：US20150266842A1

公开(公告)日：2015-09-24

申请号：US13102475

申请日：2011-05-06

申请人： Xiao-kun Zhang ,  Ying Su ,  Hu Zhou ,  Wen Liu ,  Pei-Qiang Huang

发明人： Xiao-kun Zhang ,  Ying Su ,  Hu Zhou ,  Wen Liu ,  Pei-Qiang Huang

IPC分类号： C07D295/112 ,  C07D213/55 ,  C07C255/57 ,  C07C57/62 ,  C07C59/72

CPC分类号： C07D295/112 ,  A61K38/191 ,  C07C57/62 ,  C07C59/72 ,  C07C255/57 ,  C07D213/55 ,  G01N33/5011 ,  G01N2333/70567 ,  G01N2510/00

摘要： Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenvironment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.

摘要翻译： 本文提供了与类视黄醇受体选择性途径相关的方法和组合物。 如本文所述，该途径可以靶向操纵肿瘤微环境。 例如，本文所述的方法和组合物可用于诱导癌细胞中的细胞凋亡。 此外，本文所述的组合物（包括舒林酸及其类似物）可用于靶向该途径以治疗或预防人类患者的癌症。