公开(公告)号：US5119819A

公开(公告)日：1992-06-09

申请号：US517699

申请日：1990-05-02

申请人： Graham H. Thomas ,  Roger M. Watson ,  J. Oakey Noell

发明人： Graham H. Thomas ,  Roger M. Watson ,  J. Oakey Noell

IPC分类号： A61B5/00 ,  A61B8/08 ,  G01N29/024 ,  G01N29/32

CPC分类号： A61B8/08 ,  A61B5/14532 ,  G01N29/024 ,  G01N29/326 ,  G01N2291/02466 ,  G01N2291/02809 ,  G01N2291/02881

摘要： A new and improved method and apparatus are provided for non-invasive monitoring of changes in blood glucose concentration in a tissue specimen and particularly in an individual. The method uses acoustic velocity measurements for monitoring the effect of glucose concentration upon the density and adiabatic compressibility of the serum.In a preferred embodiment, the acoustic velocity measurements are made through the earlobe of a subject by means of an acoustic probe or monitor which includes a transducer for transmitting and receiving ultrasonic energy pulses to and from the blood flowing in the subject's earlobe and a reflector for facilitating reflection of the acoustic pulses from the blood. The probe is designed in such a way that when properly affixed to an ear, the transducer is positioned flush against the anterior portion of an earlobe while the reflector is positioned flush against the interior portion of the earlobe. A microthermocouple is provided on the probe for monitoring the internal temperature of the blood being sampled.An electrical system, essentially comprising a frequency generator, a time intervalometer and an oscilloscope, is linked to the glucose monitoring probe. The electrical system analyzes selected ones of the pulses reflected from the blood sample in order to determine therefrom the acoustic velocity of the blood which, in turn, provides a representation of the blood glucose concentration levels at the time of the acoustic velocity measurements.

摘要翻译： 提供了一种新的和改进的方法和装置，用于非组织监测组织标本中，特别是个体中血糖浓度变化。 该方法使用声速测量来监测葡萄糖浓度对血清的密度和绝热压缩性的影响。 在优选实施例中，通过声探针或监视器通过主体的耳垂进行声速测量，所述声探头或监视器包括用于向从被检者的耳垂流动的血液发送和接收超声波能量脉冲的换能器和用于 促进来自血液的声脉冲的反射。 探针被设计成使得当适当地固定在耳朵上时，换能器被定位成与耳垂的前部相对齐，同时反射器被定位成与耳垂的内部部分齐平。 在探头上提供微热电偶，用于监测正在采样的血液的内部温度。 基本上包括频率发生器，时间间隔计和示波器的电气系统连接到葡萄糖监测探头。 电气系统分析从血液样本反射的所选脉冲中的所选脉冲，以便由此确定血液的声速，其进而提供在声速测量时血糖浓度水平的表示。