公开(公告)号：US07282506B2

公开(公告)日：2007-10-16

申请号：US11196532

申请日：2005-08-03

申请人： Gunnar J. Hanson ,  Roy W. Ware, Jr. ,  Thomas E. Barta ,  He Huang

发明人： Gunnar J. Hanson ,  Roy W. Ware, Jr. ,  Thomas E. Barta ,  He Huang

IPC分类号： C07D471/02 ,  A01N43/42 ,  A61K31/44

CPC分类号： C07D471/04 ,  C07D405/14

摘要： Disclosed are compounds of formula A: and pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, R3, R21, A1, A2, X, and Z are as defined herein. Compounds of formula A are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

摘要翻译： 公开了式A的化合物及其药学上可接受的盐，其中R 1，R 2，R 2，R 3， R 21，A 1，A 2，X和Z如本文所定义。 式A的化合物可用于治疗与细胞分化相关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。