公开(公告)号：US20110182929A1

公开(公告)日：2011-07-28

申请号：US13121574

申请日：2009-10-01

申请人： Rachel Schneerson ,  Joanna Kubler-Kielb ,  John B. Robbins ,  Fathy Majadly ,  Christopher P. Mocca ,  Jerry Keith ,  Zuzana Biesova ,  Louis Miller ,  Ruth Nussenzweig ,  Darrell T. Liu

发明人： Rachel Schneerson ,  Joanna Kubler-Kielb ,  John B. Robbins ,  Fathy Majadly ,  Christopher P. Mocca ,  Jerry Keith ,  Zuzana Biesova ,  Louis Miller ,  Ruth Nussenzweig ,  Darrell T. Liu

IPC分类号： A61K39/015 ,  C07K14/445 ,  G01N33/566 ,  A61P37/04 ,  A61P33/06

CPC分类号： C07K14/00 ,  A61K39/015 ,  A61K47/646 ,  Y02A50/412

摘要： Disclosed are immunogenic conjugates which elicit an immune response to Plasmodium proteins. In particular examples, the Plasmodium proteins include sexual stage surface proteins, circumsporozoite protein (CSP), or immunogenic portions of CSP. Also provided herein are immunogenic compositions including one or more of the disclosed immunogenic conjugates and a pharmaceutically acceptable carrier. Further provided is a method of eliciting an immune response to Plasmodium in a subject, comprising administering to the subject an immunogenic composition disclosed herein.

摘要翻译： 公开了引起对疟原虫蛋白质的免疫应答的免疫原性缀合物。 在具体实例中，疟原虫蛋白质包括性阶段表面蛋白质，环子孢子蛋白（CSP）或CSP的免疫原性部分。 本文还提供了包含一种或多种所公开的免疫原性缀合物和药学上可接受的载体的免疫原性组合物。 还提供了一种在受试者中引发对疟原虫的免疫应答的方法，包括向受试者施用本文公开的免疫原性组合物。

公开(公告)号：US08444996B2

公开(公告)日：2013-05-21

申请号：US13121574

申请日：2009-10-01

申请人： Rachel Schneerson ,  Joanna Kubler-Kielb ,  John B. Robbins ,  Fathy Majadly ,  Christopher P. Mocca ,  Jerry Keith ,  Zuzana Biesova ,  Louis Miller ,  Ruth Nussenzweig ,  Darrell T. Liu

发明人： Rachel Schneerson ,  Joanna Kubler-Kielb ,  John B. Robbins ,  Fathy Majadly ,  Christopher P. Mocca ,  Jerry Keith ,  Zuzana Biesova ,  Louis Miller ,  Ruth Nussenzweig ,  Darrell T. Liu

IPC分类号： A61K39/015 ,  A61K39/385

CPC分类号： C07K14/00 ,  A61K39/015 ,  A61K47/646 ,  Y02A50/412

摘要： Disclosed are immunogenic conjugates which elicit an immune response to Plasmodium proteins. In particular examples, the Plasmodium proteins include sexual stage surface proteins, circumsporozoite protein (CSP), or immunogenic portions of CSP. Also provided herein are immunogenic compositions including one or more of the disclosed immunogenic conjugates and a pharmaceutically acceptable carrier. Further provided is a method of eliciting an immune response to Plasmodium in a subject, comprising administering to the subject an immunogenic composition disclosed herein.