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公开(公告)号：US09029381B2
公开(公告)日：2015-05-12
申请号：US13300877
申请日：2011-11-21
申请人： James Arnold , Todd Andrew Brugel , Scott Throner , Steven Wesolowski , Phil Edwards , Andrew Griffin , Thierry Groblewski , Denis Labrecque
发明人： James Arnold , Todd Andrew Brugel , Scott Throner , Steven Wesolowski , Phil Edwards , Andrew Griffin , Thierry Groblewski , Denis Labrecque
IPC分类号： C07D241/04 , C07D295/00 , C07D239/26 , C07D207/27 , C07D211/76 , C07D213/56 , C07D231/12 , C07D233/36 , C07D243/08 , C07D295/182 , C07D295/185 , C07D207/12 , C07D211/40 , C07D295/18
CPC分类号： A61K31/496 , A61K31/495 , A61K31/551 , C07D207/12 , C07D207/27 , C07D211/40 , C07D211/76 , C07D213/56 , C07D231/12 , C07D233/36 , C07D239/26 , C07D243/08 , C07D295/18 , C07D295/182 , C07D295/185
摘要： Disclosed herein is at least one cyclopropyl amide derivative, at least one pharmaceutical composition comprising at least one cyclopropyl amide derivative disclosed herein, and at least one method of using at least one cyclopropyl amide derivative disclosed herein for treating at least one histamine H3 receptor associated condition therewith.
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公开(公告)号：US20070105896A1
公开(公告)日：2007-05-10
申请号：US10579609
申请日：2004-11-15
申请人： James Empfield , Eifion Phillips , Scott Throner
发明人： James Empfield , Eifion Phillips , Scott Throner
IPC分类号： A61K31/4745 , A61K31/46 , A61K31/4178 , C07D453/02
CPC分类号： C07D453/02
摘要： Compounds of formula I: wherein A and R1 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.
摘要翻译： 式I化合物：其中A和R 1如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是治疗或预防精神病和智力障碍 疾病
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公开(公告)号：US20090221579A1
公开(公告)日：2009-09-03
申请号：US11577155
申请日：2005-10-14
申请人： Jeffrey Scott Albert , Don Andisik , James Arnold , Dean Brown , Owen Callaghan , James Campbell , Robin Arthur Ellis Carr , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , James R. Empfield , Martyn Frederickson , Gerard M. Koether , Jennifer Krumrine , Russ Mauger , Christopher William Murray , Sahil Patel , Mark Sylvester , Scott Throner
发明人： Jeffrey Scott Albert , Don Andisik , James Arnold , Dean Brown , Owen Callaghan , James Campbell , Robin Arthur Ellis Carr , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , James R. Empfield , Martyn Frederickson , Gerard M. Koether , Jennifer Krumrine , Russ Mauger , Christopher William Murray , Sahil Patel , Mark Sylvester , Scott Throner
IPC分类号： A61K31/5377 , C07D239/47 , A61K31/513 , C07D413/10 , C12N9/99 , A61P25/28
CPC分类号： C07D239/47 , C07D401/06 , C07D401/08 , C07D403/08 , C07D405/08 , C07D405/12 , C07D405/14 , C07D409/08
摘要： This invention relates to novel compounds having the structural formula Ia or formula Ib: Ia Ib and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of Aβ related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译： 本发明涉及具有结构式Ia或式Ib：Ia Ib的新化合物及其药学上可接受的盐，互变异构体或体内可水解的前体，组合物及其使用方法。 这些新型化合物提供治疗或预防Abeta相关病理学，如认知障碍，阿尔茨海默病，神经变性和痴呆。
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4.发明授权Metabotropic glutamate receptor isoxazole ligands and their use as potentiators—286 有权代谢型谷氨酸受体异恶唑配体及其作为增效剂的用途 - 286公开(公告)号：US08148372B2
公开(公告)日：2012-04-03
申请号：US12860330
申请日：2010-08-20
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/422 , C07D261/18
CPC分类号： A61B17/083 , A61B17/085 , A61B17/10 , A61B17/105 , C07D413/04
摘要： Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译： 符合式I的化合物：其中R 1，R 2，R 3和R 4如说明书中所定义，药学上可接受的盐，制备方法，药物组合物及其使用方法。
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公开(公告)号：US20100317662A1
公开(公告)日：2010-12-16
申请号：US12860330
申请日：2010-08-20
IPC分类号： A61K31/5377 , C07D413/02 , C07D413/14 , A61K31/422 , A61K31/496 , A61P25/18 , A61P25/00
CPC分类号： A61B17/083 , A61B17/085 , A61B17/10 , A61B17/105 , C07D413/04
摘要： Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
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6.发明授权Metabotropic glutamate receptor isoxazole ligands and their use as potentiators—286 有权代谢型谷氨酸受体异恶唑配体及其作为增效剂的用途 - 286公开(公告)号：US07781434B2
公开(公告)日：2010-08-24
申请号：US12575891
申请日：2009-10-08
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： A61B17/083 , A61B17/085 , A61B17/10 , A61B17/105 , C07D413/04
摘要： Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译： 符合式I的化合物：其中R 1，R 2，R 3和R 4如说明书中所定义，药学上可接受的盐，制备方法，药物组合物及其使用方法。
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公开(公告)号：US20080188518A1
公开(公告)日：2008-08-07
申请号：US10579608
申请日：2004-11-15
申请人： James Empfield , Eifion Phillips , Scott Throner
发明人： James Empfield , Eifion Phillips , Scott Throner
IPC分类号： A61K31/439 , C07D453/02 , A61P25/34 , A61P25/16 , A61P25/18 , A61P25/00 , A61P25/28
CPC分类号： C07D453/02
摘要： Compounds of formula I: wherein A and R1 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.
摘要翻译： 式I化合物：其中A和R 1如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是治疗或预防精神病和智力障碍 疾病
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公开(公告)号：US20120065193A1
公开(公告)日：2012-03-15
申请号：US13300877
申请日：2011-11-21
申请人： James Arnold , Andrew Todd Brugel , Scott Throner , Steven Wesolowski , Phil Edwards , Andrew Griffin , Thierry Groblewski , Denis Labrecque
发明人： James Arnold , Andrew Todd Brugel , Scott Throner , Steven Wesolowski , Phil Edwards , Andrew Griffin , Thierry Groblewski , Denis Labrecque
IPC分类号： A61K31/551 , C07D223/04 , C07D403/10 , C07D401/10 , A61P25/22 , A61P25/28 , A61P25/18 , A61P3/04 , A61P25/00 , C07D241/04 , A61K31/497
CPC分类号： A61K31/496 , A61K31/495 , A61K31/551 , C07D207/12 , C07D207/27 , C07D211/40 , C07D211/76 , C07D213/56 , C07D231/12 , C07D233/36 , C07D239/26 , C07D243/08 , C07D295/18 , C07D295/182 , C07D295/185
摘要： Disclosed herein is at least one cyclopropyl amide derivative, at least one pharmaceutical composition comprising at least one cyclopropyl amide derivative disclosed herein, and at least one method of using at least one cyclopropyl amide derivative disclosed herein for treating at least one histamine H3 receptor associated condition therewith.
摘要翻译： 本文公开了至少一种环丙基酰胺衍生物，至少一种包含本文公开的至少一种环丙基酰胺衍生物的药物组合物和至少一种使用本文公开的至少一种环丙基酰胺衍生物治疗至少一种组胺H3受体相关病症的方法 随之而来。
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9.发明授权Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 有权代谢型谷氨酸受体异恶唑配体及其作为增效剂的用途公开(公告)号：US07888353B2
公开(公告)日：2011-02-15
申请号：US12869263
申请日：2010-08-26
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： A61B17/083 , A61B17/085 , A61B17/10 , A61B17/105 , C07D413/04
摘要： Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译： 符合式I的化合物：其中R 1，R 2，R 3和R 4如说明书中所定义，药学上可接受的盐，制备方法，药物组合物及其使用方法。
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10.发明授权Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 有权代谢型谷氨酸受体异恶唑配体及其作为增效剂的用途公开(公告)号：US07790760B2
公开(公告)日：2010-09-07
申请号：US12477347
申请日：2009-06-03
IPC分类号： A61K31/422 , C07D261/18
CPC分类号： A61B17/083 , A61B17/085 , A61B17/10 , A61B17/105 , C07D413/04
摘要： Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译： 符合式I的化合物：其中R 1，R 2，R 3和R 4如说明书中所定义，药学上可接受的盐，制备方法，药物组合物及其使用方法。
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