公开(公告)号：US20060160897A1

公开(公告)日：2006-07-20

申请号：US11275258

申请日：2005-12-21

申请人： Pier Pelicci ,  Sergio Chimenti ,  Antonio Costanzo ,  Steven Nistico ,  Donatella Paolino ,  Saverio Minucci

发明人： Pier Pelicci ,  Sergio Chimenti ,  Antonio Costanzo ,  Steven Nistico ,  Donatella Paolino ,  Saverio Minucci

IPC分类号： A61K31/19

CPC分类号： A61K31/20 ,  A61K31/19 ,  A61K31/4436 ,  A61K31/505 ,  A61K2300/00

摘要： The present invention relates to a topically applicable formulation containing Valproic Acid or a derivative thereof which can be used alone or in combination with topically applicable formulations of retinoids or of nuclear receptor ligands, or of chemotherapeutic agents (e.g. 5-Fluorouracil). The formulation is useful for the topical treatment of cancerous skin disorders, such as Basal Cell Carcinoma, Squamous Cell Carcinoma, Keratoakantoma, Bowen Disease, cutaneous T-Cell Lymphoma and also for the topical treatment of pre-malignant lesions, and of inflammations of the skin and/or mucosa. The invention also relates to the use of this topically applicable formulation for the protection from UV light and for the treatment of sun burn. The invention includes the use of VPA for the manufacture of a clinically used medicament for the topical treatment of the human diseases listed above.

摘要翻译： 本发明涉及含有丙戊酸或其衍生物的局部应用制剂，其可以单独使用或与局部应用的类视黄醇或核受体配体的制剂或化学治疗剂（例如5-氟尿嘧啶）组合使用。 该制剂可用于局部治疗癌性皮肤病，例如基底细胞癌，鳞状细胞癌，角化细胞瘤，鲍氏病，皮肤T细胞淋巴瘤，以及用于局部治疗恶性前病变，以及 皮肤和/或粘膜。 本发明还涉及这种局部适用的制剂用于防止紫外线和用于治疗太阳灼伤的用途。 本发明包括使用VPA制造用于局部治疗上述人类疾病的临床用药物。