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公开(公告)号:US20100174066A1
公开(公告)日:2010-07-08
申请号:US11909275
申请日:2006-03-20
申请人: Venkataraman Sundaram , Sharat Narsapur Pandurang , Vishal Parmar Dayaram , Siva Kumar Reddy Bommareddy , Hitendra Chaudhary Sitaram
发明人: Venkataraman Sundaram , Sharat Narsapur Pandurang , Vishal Parmar Dayaram , Siva Kumar Reddy Bommareddy , Hitendra Chaudhary Sitaram
IPC分类号: C07D487/04
CPC分类号: C07D495/04
摘要: A process for preparing olanzapine Form I comprises: a) cooling a concentrated solution of olanzapine; b) isolating wet crystals of olanzapine Form I; and c) drying wet crystals and recovering olanzapine Form 1. Drying can be conducted by stepwise increases in the drying temperatures, with extended holding times at each temperature condition.
摘要翻译: 制备奥氮平形式I的方法包括:a)冷却奥氮平的浓缩溶液; b)分离奥氮平的湿结晶I型; 和c)干燥湿结晶并回收奥氮平1.形成干燥可通过逐步增加干燥温度进行,并在每个温度条件下具有延长的保持时间。