公开(公告)号：US20090175896A1

公开(公告)日：2009-07-09

申请号：US11886577

申请日：2006-03-17

Applicant: Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

Inventor： Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

IPC: A61K39/385 ,  A61K35/76 ,  C12N7/00

CPC classification number: A61K47/48776 ,  A61K39/35 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55505 ,  C07K14/005 ,  C07K2319/00

Abstract: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

Abstract translation: 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明提供包含病毒样颗粒（VLP）或病毒颗粒和至少一种抗原，特别是至少一种猫科动物抗原，更特别是至少一种作为人类变应原的猫科动物抗原的组合物。 在某些实施方案中，抗原是与VLP共价连接的Fel d1抗原或其片段。 本发明还提供了用于制备组合物的方法。 本发明的组合物在哺乳动物，特别是人类中诱导有效的免疫应答，特别是抗体应答。 本发明的组合物和方法可用于疫苗的制备，特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。

公开(公告)号：US20110045013A1

公开(公告)日：2011-02-24

申请号：US12785174

申请日：2010-05-21

Applicant: Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

Inventor： Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

IPC: A61K39/35 ,  C12N7/00 ,  A61P37/08

CPC classification number: C07K14/005 ,  A61K39/35 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55505 ,  C07K2319/00

Abstract: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

Abstract translation: 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明提供包含病毒样颗粒（VLP）或病毒颗粒和至少一种抗原，特别是至少一种猫科动物抗原，更特别是至少一种作为人类变应原的猫科动物抗原的组合物。 在某些实施方案中，抗原是与VLP共价连接的Fel d1抗原或其片段。 本发明还提供了用于制备组合物的方法。 本发明的组合物在哺乳动物，特别是人类中诱导有效的免疫应答，特别是抗体应答。 本发明的组合物和方法可用于疫苗的制备，特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。

公开(公告)号：US07767212B2

公开(公告)日：2010-08-03

申请号：US11886577

申请日：2006-03-17

Applicant: Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

Inventor： Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

IPC: A61K39/35 ,  A61K39/385 ,  C12N7/00 ,  C07K19/00 ,  C07K17/06

CPC classification number: A61K47/48776 ,  A61K39/35 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55505 ,  C07K14/005 ,  C07K2319/00

Abstract: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

Abstract translation: 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明提供包含病毒样颗粒（VLP）或病毒颗粒和至少一种抗原，特别是至少一种猫科动物抗原，更特别是至少一种作为人类变应原的猫科动物抗原的组合物。 在某些实施方案中，抗原是与VLP共价连接的Fel d1抗原或其片段。 本发明还提供了用于制备组合物的方法。 本发明的组合物在哺乳动物，特别是人类中诱导有效的免疫应答，特别是抗体应答。 本发明的组合物和方法可用于疫苗的制备，特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。