公开(公告)号：US08003802B2

公开(公告)日：2011-08-23

申请号：US12399382

申请日：2009-03-06

申请人： Taotao Ling ,  Samuel Danishefsky

发明人： Taotao Ling ,  Samuel Danishefsky

IPC分类号： C07D498/14 ,  C07D487/04

CPC分类号： C07D487/14 ,  C07D487/04

摘要： The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).

摘要翻译： 本申请涉及某些化合物和制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地说，本文描述了合成Salinosporamide A及其类似物的方法，其包括形成式（VIII）化合物。

公开(公告)号：US20130012720A1

公开(公告)日：2013-01-10

申请号：US13619568

申请日：2012-09-14

申请人： Taotao Ling ,  Samuel Danishefsky

发明人： Taotao Ling ,  Samuel Danishefsky

IPC分类号： C07D498/04

CPC分类号： C07D487/14 ,  C07D487/04

摘要： The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).

公开(公告)号：US07842814B2

公开(公告)日：2010-11-30

申请号：US11697689

申请日：2007-04-06

申请人： Taotao Ling ,  Venkata Rami Reddy Macherla ,  Barbara Christine Potts ,  Rama Rao Manam ,  Katherine A. McArthur

发明人： Taotao Ling ,  Venkata Rami Reddy Macherla ,  Barbara Christine Potts ,  Rama Rao Manam ,  Katherine A. McArthur

IPC分类号： C07D413/02 ,  C07D265/04 ,  C07D498/02 ,  C07D487/02 ,  C07D207/08

CPC分类号： C07D491/048 ,  C07D207/28 ,  Y02P20/55

摘要： The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V).

摘要翻译： 本发明涉及某些化合物以及制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地，本文描述了由式（V）化合物合成盐霉素A及其类似物的方法。

公开(公告)号：US20090234137A1

公开(公告)日：2009-09-17

申请号：US12399382

申请日：2009-03-06

申请人： Taotao Ling ,  Samuel Danishefsky

发明人： Taotao Ling ,  Samuel Danishefsky

IPC分类号： C07D487/14 ,  C07D487/04

CPC分类号： C07D487/14 ,  C07D487/04

摘要： The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).

摘要翻译： 本申请涉及某些化合物和制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地说，本文描述了合成Salinosporamide A及其类似物的方法，其包括形成式（VIII）化合物。

公开(公告)号：US08314251B2

公开(公告)日：2012-11-20

申请号：US13184356

申请日：2011-07-15

申请人： Taotao Ling ,  Samuel Danishefsky

发明人： Taotao Ling ,  Samuel Danishefsky

IPC分类号： C07D263/00 ,  C07D498/04

CPC分类号： C07D487/14 ,  C07D487/04

摘要： The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).

摘要翻译： 本申请涉及某些化合物和制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地说，本文描述了合成Salinosporamide A及其类似物的方法，其包括形成式（VIII）化合物。

公开(公告)号：US20110269969A1

公开(公告)日：2011-11-03

申请号：US13184356

申请日：2011-07-15

申请人： Taotao Ling ,  Samuel Danishefsky

发明人： Taotao Ling ,  Samuel Danishefsky

IPC分类号： C07D498/04 ,  C07D491/048

CPC分类号： C07D487/14 ,  C07D487/04

摘要： The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).

摘要翻译： 本申请涉及某些化合物和制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地说，本文描述了合成Salinosporamide A及其类似物的方法，其包括形成式（VIII）化合物。

公开(公告)号：US20110105762A1

公开(公告)日：2011-05-05

申请号：US12913624

申请日：2010-10-27

申请人： Taotao Ling ,  Venkata Rami Reddy Macherla ,  Barbara Christine Potts ,  Rama Rao Manam ,  Katherine A. McArthur

发明人： Taotao Ling ,  Venkata Rami Reddy Macherla ,  Barbara Christine Potts ,  Rama Rao Manam ,  Katherine A. McArthur

IPC分类号： C07D498/14 ,  C07D491/044 ,  C07D491/048 ,  C07D498/04

CPC分类号： C07D491/048 ,  C07D207/28 ,  Y02P20/55

摘要： The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V).

摘要翻译： 本发明涉及某些化合物以及制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地，本文描述了由式（V）化合物合成盐霉素A及其类似物的方法。

公开(公告)号：US20070249693A1

公开(公告)日：2007-10-25

申请号：US11697689

申请日：2007-04-06

申请人： Taotao Ling ,  Venkata Macherla ,  Barbara Potts ,  Rama Manam ,  Katherine McArthur

发明人： Taotao Ling ,  Venkata Macherla ,  Barbara Potts ,  Rama Manam ,  Katherine McArthur

IPC分类号： A61K31/424 ,  C07D491/02

CPC分类号： C07D491/048 ,  C07D207/28 ,  Y02P20/55

摘要： The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V).

摘要翻译： 本发明涉及某些化合物以及制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地，本文描述了由式（V）化合物合成盐霉素A及其类似物的方法。

公开(公告)号：US08067616B2

公开(公告)日：2011-11-29

申请号：US12913624

申请日：2010-10-27

申请人： Taotao Ling ,  Venkata Rami Reddy Macherla ,  Barbara Christine Potts ,  Rama Rao Manam ,  Katherine A. McArthur

发明人： Taotao Ling ,  Venkata Rami Reddy Macherla ,  Barbara Christine Potts ,  Rama Rao Manam ,  Katherine A. McArthur

IPC分类号： C07D487/02

CPC分类号： C07D491/048 ,  C07D207/28 ,  Y02P20/55

摘要： The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V).

摘要翻译： 本发明涉及某些化合物以及制备可用于化学和医学领域的某些化合物的方法。 具体来说，本文描述了制备各种化合物和中间体以及化合物和中间体本身的方法。 更具体地，本文描述了由式（V）化合物合成盐霉素A及其类似物的方法。