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1.发明授权公开(公告)号：US08779003B2
公开(公告)日：2014-07-15
申请号：US13340330
申请日：2011-12-29
申请人： Yu-Chun Hung
发明人： Yu-Chun Hung
IPC分类号： A01N37/18 , A61K31/165 , A61K31/16 , A01N35/00 , A61K31/11 , C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00 , C07C321/00 , C07C323/00 , C07C381/00 , C07C47/00
CPC分类号： A61K31/11 , A61K31/167 , A61K31/381 , A61K31/445 , A61K31/4545 , A61K31/47 , A61K45/06 , A61K2300/00
摘要： Disclosed herein is a method for prolonging analgesic effect of a membrane permeable local anesthetic in a subject in need thereof. The method uses cinnamaldehyde as an adjuvant which, when administered prior to or simultaneously with the administration of a local anesthetic, prolongs the analgesic effect of the local anesthetic. Also disclosed herein is a method for providing analgesic effect in a subject in need thereof. The method uses cinnamaldehyde as an analgesic compound which, when administered alone to the subject in an analgesically effective amount, provides the analgesic effect.
摘要翻译： 本文公开了一种延长可渗透局部麻醉剂在有需要的受试者中的镇痛作用的方法。 该方法使用肉桂醛作为佐剂，当在施用局部麻醉剂之前或同时施用时，其延长局部麻醉剂的镇痛作用。 本文还公开了一种在有需要的受试者中提供止痛效果的方法。 该方法使用肉桂醛作为止痛化合物，当以镇痛有效量单独给予受试者时，其提供镇痛作用。
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2.发明申请公开(公告)号：US20100178345A1
公开(公告)日：2010-07-15
申请号：US12729376
申请日：2010-03-23
申请人： Yu-Chun Hung , Chi-Shu Wei , Lien-Hua Chiu , Wen-Yen Chiu , Chia-Jen Wen
发明人： Yu-Chun Hung , Chi-Shu Wei , Lien-Hua Chiu , Wen-Yen Chiu , Chia-Jen Wen
IPC分类号： A61K9/14 , A61K31/722 , A61P31/00
CPC分类号： A61K9/5026 , A61L15/28 , A61L15/60 , C08L5/08
摘要： Disclosed herein is a method for preparing a hydrogel microparticle composition. A dispersion including 1 part by weight of N-isopropyl acrylamide, about 0.1-0.5 part by weight of chitosan, about 0-0.05 part by weight of N,N′-methylene bisacrylamide, about 0.1-0.5 part by weight of glacial acetic acid, and about 20-40 parts by weight of water is prepared. About 0.01-0.3 part by weight of an anionic initiator is added into the dispersion and the dispersion is allowed to undergo a polymerization reaction at a temperature of about 10-100° C. for about 1 to 5 hours, thereby producing a plurality of hydrogel microparticles dispersed in the water to form the hydrogel microparticle composition.
摘要翻译： 本文公开了一种制备水凝胶微粒组合物的方法。 包含1重量份的N-异丙基丙烯酰胺，约0.1-0.5重量份的壳聚糖，约0-0.05重量份的N，N'-亚甲基双丙烯酰胺，约0.1-0.5重量份的冰醋酸 ，制备约20-40重量份的水。 将约0.01-0.3重量份的阴离子引发剂加入到分散体中，使分散体在约10-100℃的温度下进行聚合反应约1至5小时，从而产生多个水凝胶 微粒分散在水中以形成水凝胶微粒组合物。
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公开(公告)号：US20070088104A1
公开(公告)日：2007-04-19
申请号：US11546468
申请日：2006-10-11
申请人： Yu-Chun Hung , Chi-Shu Wei , Chen-An Ku , Yen-Hsi Lin
发明人： Yu-Chun Hung , Chi-Shu Wei , Chen-An Ku , Yen-Hsi Lin
CPC分类号： C08L5/00 , A61K8/0208 , A61K8/042 , A61K8/11 , A61K8/345 , A61K8/37 , A61K8/65 , A61K8/731 , A61K8/736 , A61K8/8176 , A61K8/86 , A61K2800/242 , A61K2800/412 , A61Q19/00 , C08L1/286 , C08L5/06 , C08L5/08
摘要： A temperature regulating gel includes a hydrophilic polymeric substrate and a heat-storing material. The hydrophilic polymeric substrate may include a natural hydrogel, a synthetic hydrogel, or any combination thereof. The heat-storing material may include a phase change material, a plastic crystal, or any combination thereof. The present invention also discloses a temperature regulating article including the temperature regulating gel.
摘要翻译： 温度调节凝胶包括亲水性聚合物基材和储热材料。 亲水聚合物基底可以包括天然水凝胶，合成水凝胶或其任何组合。 储热材料可以包括相变材料，塑料晶体或其任何组合。 本发明还公开了一种包括温度调节凝胶的温度调节制品。
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4.发明申请公开(公告)号：US20130172387A1
公开(公告)日：2013-07-04
申请号：US13340330
申请日：2011-12-29
申请人： Yu-Chun HUNG
发明人： Yu-Chun HUNG
IPC分类号： A61K31/11 , A61P23/02 , A61P25/04 , A61K31/167 , A61K31/445
CPC分类号： A61K31/11 , A61K31/167 , A61K31/381 , A61K31/445 , A61K31/4545 , A61K31/47 , A61K45/06 , A61K2300/00
摘要： Disclosed herein is a method for prolonging analgesic effect of a membrane permeable local anesthetic in a subject in need thereof. The method uses cinnamaldehyde as an adjuvant which, when administered prior to or simultaneously with the administration of a local anesthetic, prolongs the analgesic effect of the local anesthetic. Also disclosed herein is a method for providing analgesic effect in a subject in need thereof. The method uses cinnamaldehyde as an analgesic compound which, when administered alone to the subject in an analgesically effective amount, provides the analgesic effect.
摘要翻译： 本文公开了一种延长可渗透局部麻醉剂在有需要的受试者中的镇痛作用的方法。 该方法使用肉桂醛作为佐剂，当在施用局部麻醉剂之前或同时施用时，其延长局部麻醉剂的镇痛作用。 本文还公开了一种在有需要的受试者中提供止痛效果的方法。 该方法使用肉桂醛作为止痛化合物，当以镇痛有效量单独给予受试者时，其提供镇痛作用。
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5.发明授权公开(公告)号：US08173171B2
公开(公告)日：2012-05-08
申请号：US12729376
申请日：2010-03-23
申请人： Yu-Chun Hung , Chi-Shu Wei , Lien-Hua Chiu , Wen-Yen Chiu , Chia-Jen Wen
发明人： Yu-Chun Hung , Chi-Shu Wei , Lien-Hua Chiu , Wen-Yen Chiu , Chia-Jen Wen
IPC分类号： A61K9/14
CPC分类号： A61K9/5026 , A61L15/28 , A61L15/60 , C08L5/08
摘要： Disclosed herein is a method for preparing a hydrogel microparticle composition. A dispersion including 1 part by weight of N-isopropyl acrylamide, about 0.1-0.5 part by weight of chitosan, about 0-0.05 part by weight of N,N′-methylene bisacrylamide, about 0.1-0.5 part by weight of glacial acetic acid, and about 20-40 parts by weight of water is prepared. About 0.01-0.3 part by weight of an anionic initiator is added into the dispersion and the dispersion is allowed to undergo a polymerization reaction at a temperature of about 10-100° C. for about 1 to 5 hours, thereby producing a plurality of hydrogel microparticles dispersed in the water to form the hydrogel microparticle composition.
摘要翻译： 本文公开了一种制备水凝胶微粒组合物的方法。 包含1重量份的N-异丙基丙烯酰胺，约0.1-0.5重量份的壳聚糖，约0-0.05重量份的N，N'-亚甲基双丙烯酰胺，约0.1-0.5重量份的冰醋酸 ，制备约20-40重量份的水。 将约0.01-0.3重量份的阴离子引发剂加入到分散体中，使分散体在约10-100℃的温度下进行聚合反应约1至5小时，从而产生多个水凝胶 微粒分散在水中以形成水凝胶微粒组合物。
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