公开(公告)号：US20060050946A1

公开(公告)日：2006-03-09

申请号：US10435827

申请日：2003-05-12

Applicant: Timothy Mitchison ,  Steven Altschuler ,  Yan Feng ,  Thomas Mayer ,  Zachary Perlman ,  Michael Slack ,  Lani Wu

Inventor： Timothy Mitchison ,  Steven Altschuler ,  Yan Feng ,  Thomas Mayer ,  Zachary Perlman ,  Michael Slack ,  Lani Wu

IPC: G06K9/00

CPC classification number: G06K9/0014 ,  G06T7/0012 ,  G06T2207/30024

Abstract: The present invention provides methods and systems for automated morphological analysis of cells. The inventive methods are particularly useful in the rapid analysis of cells required in a biological screen. Agents which cause a particular phenotype in the cells can be identified using the inventive quantitative morphometric analysis of cells. The data gathered using the inventive method can also be quantified and analyzed later for various trends and classifications. Characteristics of cells which can be determined using this method include number of nuclei, size of cell, size of nuclei, number of the centrosomes, shape of cells, size of centrosomes, perimeter of nucleus, shape of nucleus, pattern of staining, and degree of staining.

Abstract translation: 本发明提供了用于细胞自动形态学分析的方法和系统。 本发明的方法在生物屏幕中所需的细胞的快速分析中特别有用。 可以使用本发明的细胞定量形态学分析来鉴定在细胞中引起特定表型的药剂。 使用本发明方法收集的数据也可以针对各种趋势和分类进行量化和分析。 可以使用该方法确定的细胞的特征包括细胞核的数量，细胞的大小，细胞核的大小，中心体的数量，细胞的形状，中心体的大小，细胞核的周长，细胞核的形状，染色的图案和程度 的染色。