公开(公告)号：US20230357500A1

公开(公告)日：2023-11-09

申请号：US18004910

申请日：2021-06-14

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Carl A. Laskowski ,  Timothy M. Gillard ,  Ranjani V. Parthasarathy ,  Hannah C. Cohen ,  Max A. Kruziki

IPC: C08G65/327 ,  C08G65/08 ,  C08G81/00 ,  A61K31/80

CPC classification number: C08G65/327 ,  C08G65/08 ,  C08G81/00 ,  A61K31/80 ,  C08G2650/58

Abstract: Phosphate-containing copolymers, medical compositions containing the phosphate-containing copolymers, and methods of suppressing microbial virulence are provided. By suppressing virulence, administration and/or application of the medical compositions can be used to prevent, mitigate, or treat a microbial infection. The phosphate-containing copolymers are prepared by phosphorylating either a random copolymer or a random copolymeric block that contains monomeric units of propylene oxide and glycidol.

公开(公告)号：US20230302045A1

公开(公告)日：2023-09-28

申请号：US18004940

申请日：2021-06-14

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Semra Colak Atan ,  Hannah C. Cohen ,  Max A. Kruziki ,  Ranjani V. Parthasarathy ,  Matthew T. Scholz

IPC: A61K31/80 ,  A61P31/04

CPC classification number: A61K31/80 ,  A61P31/04

Abstract: Medical compositions and methods of suppressing microbial virulence are provided. By suppressing virulence, administration and/or application of the medical compositions can be used to prevent, mitigate, or treat a microbial infection. More specifically, the medical compositions include a phosphonate-containing polymer. The phosphonate-containing polymers can suppress the expression of various virulence factors without destroying all microbes that may be present.