公开(公告)号：US20190030120A1

公开(公告)日：2019-01-31

申请号：US15660116

申请日：2017-07-26

Applicant: ACADEMIA SINICA

Inventor： Ming-Daw TSAI ,  Tong-You Wade WEI ,  Pei-Yu WU

IPC: A61K38/17 ,  C07K14/47 ,  A61K45/06 ,  C12N15/113

Abstract: The present invention relates to use of TRAF-interacting protein with an FHA domain (TIFA) antagonists for treating diseases. Particularly, the present invention relates to an isolated peptide fragment from TIFA which acts as a dominant negative inhibitor of TIFA and is effective in treating cancer or an inflammatory disorder. The present invention also relates to a method for predicting cancer prognosis based on the TIFA expression level in a subject in need. The present invention further relates to a method for treating a disease via TIFA silencing.