公开(公告)号：US20200095566A1

公开(公告)日：2020-03-26

申请号：US16495987

申请日：2018-03-08

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Dave Siak Wei OW ,  Fong Tian WONG

IPC: C12N9/64 ,  A61K35/747 ,  A61K35/744

Abstract: The invention relates generally to the field of microbiology and molecular biology. Provided herein is an expression construct for producing a recombinant protein. The subject specification discloses an expression construct for producing a prolyl endopeptidase protein in lactic acid bacteria and methods of treatment comprising use of such a prolyl endopeptidase.

公开(公告)号：US20160297820A1

公开(公告)日：2016-10-13

申请号：US14917935

申请日：2014-09-09

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yiqi SEOW ,  Fong Tian WONG ,  Yin Nah TEO

IPC: C07D473/18

CPC classification number: C07D473/18 ,  A61K38/00 ,  A61K47/55 ,  A61K47/60

Abstract: There is provided a compound comprising at least two ligands that are individually coupled to a linker, wherein each ligand is independently selected from the group consisting of a substituted benzylguanine derivative, a substituted benzylcytosine derivative, a haloalkyl moiety, a drug, a peptide, a hormone, an inorganic compound and a protein. The compound may be part of an oligomer. The compound may be employed in a method of dimerizing a pair of proteins, which may alter a biological function in a cell. There is also provided a method of forming the compound.

Abstract translation: 提供了包含至少两个分别与接头偶联的配体的化合物，其中每个配体独立地选自取代的苄基鸟嘌呤衍生物，取代的苄基胞嘧啶衍生物，卤代烷基部分，药物，肽， 激素，无机化合物和蛋白质。 该化合物可以是低聚物的一部分。 该化合物可以用于二聚化一对蛋白质的方法，这可能改变细胞中的生物学功能。 还提供了形成化合物的方法。