公开(公告)号：US10684272B2

公开(公告)日：2020-06-16

申请号：US15745431

申请日：2016-07-15

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Ee Chee Ren ,  Hul Ling Ko

IPC: A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  G01N33/50 ,  A61K38/17 ,  C07K14/00 ,  C07K14/02 ,  A61P1/16 ,  A61P31/20 ,  A61K31/713 ,  G01N33/576

Abstract: Presently disclosed is a method of modulating Hepatitis B virus (HBV) replication, by contacting the cell with at least one agent that modulates at least one factor from a specified group consisting of SNAI2, SOX7 and other factors, the screening of said agent and use thereof in a medicament for treating HBV infection or disease or condition associated with a HBV infection in a subject. In one preferred embodiment, the agent is one peptide derived from SOX7 or SNAI2 or stapled peptides thereof. As a separate invention, a method of identifying at least one factor that modulates replication of a virus is also disclosed.