公开(公告)号：US20220096604A1

公开(公告)日：2022-03-31

申请号：US17426756

申请日：2020-01-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Wenn-Chyau LEE ,  Laurent RENIA

IPC: A61K38/36 ,  A61K38/18 ,  A61K31/366 ,  A61K31/357 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/635 ,  A61K31/65 ,  A61K31/137 ,  A61K31/155 ,  A61P33/06

Abstract: The invention relates to a composition comprising insulin growth factor binding protein 7 (IGFBP7) for treating malaria or reducing the phenomenon of IRB C-endothelial cytoadherence. The composition can further comprise Von Willebrand Factor (VWF) and/or thrombospondin-1 (TSP-1). The composition can also be used as an adjunct therapeutic agent alongside other anti-malarial drugs.