公开(公告)号：US10176573B2

公开(公告)日：2019-01-08

申请号：US15519145

申请日：2014-10-13

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Zujun Hou ,  Yue Wang

IPC: G06T7/00 ,  G06K9/46 ,  G06T7/73 ,  G06T7/12 ,  G06T7/33 ,  G06T7/246 ,  G01R33/56

Abstract: A method for dynamic contrast enhanced (DCE) image processing and kinetic modeling of an organ's region-of-interest is provided. The method includes deriving at least a contour of an exterior of the organ's region-of-interest from one or more of a plurality of images; generating a spline function in response to the derived contour of the exterior of the organ's region-of-interest from the one or more of the plurality of images; registering the plurality of images wherein the organ's region-of-interest has been segmented; deriving a tracer curve for the organ's region-of-interest in the registered images, the tracer curve indicating a change in concentration of a contrast agent flowing through the organ's region-of-interest over a time period; and kinetic modeling by fitting a kinetic model to the tracer curve to generate one or more maps of tissue physiological parameters associated with the kinetic model.