公开(公告)号：US20180243421A1

公开(公告)日：2018-08-30

申请号：US15962250

申请日：2018-04-25

Applicant: AJINOMOTO CO., INC.

Inventor： Kenji TANAKA ,  Shigekazu KURIHARA ,  Wataru KUROSAWA ,  Hiroshi UMISHIO

IPC: A61K47/18 ,  A61K47/64 ,  A61K9/00

CPC classification number: A61K47/183 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K31/195 ,  A61K47/646 ,  C07C233/47 ,  C07C237/22 ,  C07C279/14

Abstract: Compounds represented by formula (I): defined herein and salts thereof, and compounds represented by formula (II): defined herein and salts thereof, exhibit superior immunostimulatory effects, and are useful as vaccine adjuvants and in vaccines containing such a compound and an antigen.

公开(公告)号：US20180311342A1

公开(公告)日：2018-11-01

申请号：US15964674

申请日：2018-04-27

Applicant: AJINOMOTO CO., INC.

Inventor： Kayo MATSUMOTO ,  Wataru KUROSAWA ,  Kenji TANAKA ,  Takuya SEKI ,  Hiroshi UMISHIO

IPC: A61K39/39 ,  C07C323/60 ,  C07C323/59 ,  C07C323/52

CPC classification number: C07C323/00 ,  A61K45/00 ,  C07C237/22 ,  C07C257/14 ,  C07C271/22 ,  C07C275/16 ,  C07C279/12 ,  C07C279/14 ,  C07C323/60 ,  C07D201/00 ,  C07D295/00

Abstract: The present invention aims to provide an immunostimulating agent superior in an immunostimulatory effect, particularly a compound useful as a vaccine adjuvant, a pharmaceutical composition containing the compound, a vaccine containing the compound and an antigen.An immunostimulating agent containing at least one kind of a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.

公开(公告)号：US20170036999A1

公开(公告)日：2017-02-09

申请号：US15331094

申请日：2016-10-21

Applicant: AJINOMOTO CO., INC.

Inventor： Shigekazu KURIHARA ,  Kenji TANAKA ,  Wataru KUROSAWA ,  Hiroshi UMISHIO

IPC: C07C323/52 ,  A61K39/39

CPC classification number: C07C323/52 ,  A61K39/39 ,  A61K2039/55511

Abstract: Compounds represented by formula (I): wherein each symbol is as defined herein, have an immunostimulatory effect and are useful as immunostimulating agents, particularly as adjuvants, and for compositions containing such a compound, and for vaccines containing such a compound and an antigen.

Abstract translation: 其中每个符号如本文所定义，具有免疫刺激作用，并且可用作免疫刺激剂，特别是作为佐剂，以及用于含有这种化合物的组合物和含有这种化合物和抗原的疫苗。