公开(公告)号：US11261475B2

公开(公告)日：2022-03-01

申请号：US16311161

申请日：2017-05-12

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Tae Hwan Shin ,  Geetika Phukan ,  Man Jeong Paik ,  Hyeon-Seong Lee ,  Hyung-Jin Park ,  Da Yeon Lee ,  Gwang Lee

IPC: C12Q1/02 ,  C12Q1/6883 ,  C12Q1/6837 ,  C12Q1/6881

Abstract: A method of assessing neurotoxicity of nanoparticles, includes: preparing a tissue or cell sample of mammal exposed to the nanoparticles; analyzing at least one polyamine metabolite selected from the group consisting of putrescine, N1-acetylspermidine, N8-acetylspermidine, N1-acetylspermine and spermine in the sample; and comparing expression degree of the polyamine metabolite with that of a control.