公开(公告)号：US20150291595A1

公开(公告)日：2015-10-15

申请号：US14435851

申请日：2013-10-15

Applicant: ALMIRALL, S.A.

Inventor： Montserrat Erra Sola ,  Marta Carrascal Riera ,  Joan Taltavull Moll ,  Juan Francisco Caturla Javaloyes ,  Francisco Javier Bernal Anchuela ,  Lluis Miquel Pages Santacana ,  Marta Mir Cepeda ,  Gaspar Casals Coll ,  Maria Begoña Hernandez Olasagarre

IPC: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  A61K31/53

CPC classification number: C07D487/04 ,  A61K31/53 ,  A61K45/06 ,  C07D519/00

Abstract: New pyrrolotriazinone derivatives having the chemical structure of Formula (I) are disclosed; as well as process for theft preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).

Abstract translation: 公开了具有式（I）化学结构的新的吡咯并三嗪酮衍生物; 以及盗窃制备方法，包含它们的药物组合物及其在治疗中作为磷酸肌醇3-激酶（PI3Ks）抑制剂的用途。

公开(公告)号：US09388189B2

公开(公告)日：2016-07-12

申请号：US14435851

申请日：2013-10-15

Applicant: ALMIRALL, S.A.

Inventor： Montserrat Erra Sola ,  Marta Carrascal Riera ,  Joan Taltavull Moll ,  Juan Francisco Caturla Javaloyes ,  Francisco Javier Bernal Anchuela ,  Lluis Miquel Pages Santacana ,  Marta Mir Cepeda ,  Gaspar Casals Coll ,  Maria Begoña Hernandez Olasagarre

IPC: C07D487/04 ,  C07D519/00 ,  A61K31/53 ,  A61P11/06 ,  A61P11/00 ,  A61K45/06

CPC classification number: C07D487/04 ,  A61K31/53 ,  A61K45/06 ,  C07D519/00

Abstract: New pyrrolotriazinone derivatives having the chemical structure of Formula (I) are disclosed; as well as process for theft preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).

Abstract translation: 公开了具有式（I）化学结构的新的吡咯并三嗪酮衍生物; 以及盗窃制备方法，包含它们的药物组合物及其在治疗中作为磷酸肌醇3-激酶（PI3Ks）抑制剂的用途。