公开(公告)号：US20210087286A1

公开(公告)日：2021-03-25

申请号：US16623750

申请日：2018-06-20

Applicant: AMGEN INC.

Inventor： Darren L. BATES ,  Donghui SHI ,  David J. LLOYD ,  Pavel BONDARENKO ,  Mark L. MICHAELS ,  Todd HAGER ,  Xiaoshan MIN ,  Aiko UMEDA ,  Irwin CHEN ,  Zhulun WANG

IPC: C07K16/28 ,  A61K38/26

Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.