公开(公告)号：US20250127782A1

公开(公告)日：2025-04-24

申请号：US18689716

申请日：2022-09-07

Applicant: AMGEN INC.

Inventor： Emily CHAN ,  Gregory FRIBERG ,  Omar Ali MATHER ,  Brett E. HOUK ,  Gataree NGARMCHAMNANRITH ,  Haby HENARY ,  Sandeep DUTTA

IPC: A61K31/519 ,  A61K31/4745 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

Abstract: Provided herein are methods of treating cancer comprising a KRAS G12C mutation in a patient comprising administering to the patient sotorasib and an anti-epidermal growth factor receptor (EGFR) antibody in amounts effective to treat the cancer. Further provided herein are methods further comprising administering FOLFIRI (irinotecan, 5-FU and leucovorin) to the patient.