公开(公告)号：US20230312602A1

公开(公告)日：2023-10-05

申请号：US18296215

申请日：2023-04-05

Applicant: AMGEN INC.

Inventor： Henry Morrison ,  Jason S. Tedrow ,  Stephan D. Parent ,  Courtney Johnson ,  Travis Houston ,  Melanie Bevill

IPC: C07D513/08

CPC classification number: C07D513/08 ,  C07B2200/13

Abstract: Disclosed herein are salt and solvate forms of. (1S,3′R,6′R,7′S,8′E,11′S,12′R)-6-chloro-7′-methoxy-11′,12′-dimethyl-3,4-dihydro-2H,15′H-spiro[naphthalene-1,22′-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.03,6.019,24]pentacosa[8,16,18,24]tetraen]-15′-one 13′,13′-dioxide (AMG 176):




such as crystalline salt and solvate forms thereof. Also disclosed are methods of making the salt and solvate forms, and methods of treating diseases and disorders with the salt and solvate forms.