公开(公告)号：US20240261289A1

公开(公告)日：2024-08-08

申请号：US18562107

申请日：2022-05-17

Applicant: AMGEN INC.

Inventor： Haby HENARY ,  Gataree NGARMCHAMNANRITH ,  Joseph PARK ,  Sandeep DUTTA ,  Gregory FRIBERG ,  Brett E. HOUK ,  Omar MATHER

IPC: A61K31/519 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K45/06 ,  A61P35/00

Abstract: Provided herein are methods of treating a cancer comprising a KRAS G12C mutation in a patient with active brain metastases, comprising administering sotorasib to the patient in amount effective to treat the cancer.