公开(公告)号：US20220187398A1

公开(公告)日：2022-06-16

申请号：US17442891

申请日：2020-03-26

Applicant: AMGEN INC.

Inventor： Tsang-Lin HWANG ,  Mats H. WIKSTROEM

IPC: G01R33/46 ,  G01R33/465

Abstract: Methods of fingerprinting a specific molecule in a composition using nuclear magnetic resonance (NMR) is disclosed. The disclosed NMR methods provide several modifications and improvements over existing NMR techniques. In some embodiments, the methods include applying a cycle of signal processing steps, including applying a radio frequency (RF) pulse, applying a gradient pulse having a pulse length less than or equal to 1000 μs, and applying a water suppression technique (WET). In some embodiments, the methods further include repeating the cycle for at least 3 times to acquire an enhanced signal of the composition. In some embodiments, the methods further include fingerprinting the specific molecule based on the enhanced signal of the composition