公开(公告)号：US20250163064A1

公开(公告)日：2025-05-22

申请号：US18838954

申请日：2023-02-15

Applicant: AMGEN INC.

Inventor： Brian Alan Lanman ,  Ryan Paul Wurz ,  Wei Zhao ,  Xiaofen LI ,  Michael YAMANO ,  Imelda HOT ,  Rene RAHIMOFF ,  Liping Pettus ,  Jose Medina

IPC: C07D487/04 ,  A61K31/517 ,  A61K31/519 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554 ,  C07D519/00

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S or G12C. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.