公开(公告)号：US20220401643A1

公开(公告)日：2022-12-22

申请号：US17763692

申请日：2020-10-14

Applicant: AMGEN INC.

Inventor： Scott R. Gibson ,  Paul D. Faucher ,  Mehran Mojarrad

IPC: A61M5/148

Abstract: A drug delivery device includes a drug product container, a pressurized vessel, and an urging member. The drug product container can have at least one flexible wall and defining a cavity configured to contain a drug product. The pressurized vessel can contain a gas under pressure. And the urging member is in working connection with the pressurized vessel such that, upon at least partial release of the gas under pressure, the urging member moves from a first portion of the drug product container to a second portion, thereby ejecting at least a portion of the drug product from the drug product container.

公开(公告)号：US12070582B2

公开(公告)日：2024-08-27

申请号：US17094176

申请日：2020-11-10

Applicant: AMGEN INC.

Inventor： Mehran Mojarrad ,  Ali Nekouzadeh ,  Susan McConnell Montalvo ,  Scott R. Gibson ,  Sheldon B. Moberg ,  Joshua Tamsky ,  Paul D. Faucher

IPC: A61M5/315

CPC classification number: A61M5/31513 ,  A61M2005/3152

Abstract: Drug delivery devices are configured to include a gas-driven piston assembly having a flexible pushrod, a non-linear guide include a non-linear guide pathway at least partially surrounding the flexible pushrod, a cylinder at least partially surrounding the flexible pushrod, and a piston movable within the cylinder in response to the pressurized gas entering the cylinder. Some arrangements include a roller pushrod guide system and/or a gear pushrod guide system.

公开(公告)号：US20240091440A1

公开(公告)日：2024-03-21

申请号：US17767469

申请日：2020-10-16

Applicant: AMGEN INC.

Inventor： Scott R. Gibson ,  Mehran Mojarrad ,  Paul D. Faucher ,  Antonio S. Murcia ,  Alan D. Payne ,  Sheldon Moberg ,  Olivia Li

IPC: A61M5/172 ,  A61M5/142 ,  A61M39/10

CPC classification number: A61M5/1723 ,  A61M5/14244 ,  A61M39/10 ,  A61M2205/3331

Abstract: A drug delivery device for delivering a medicament includes a housing, a pump, drive component, an inlet fluid path, an outlet fluid path, an inlet pressure sensor, an outlet pressure sensor, and a controller. The pump is coupled with the housing. The drive component is for driving the pump. The inlet fluid path is configured to deliver medicament to the pump. The outlet fluid path is configured to receive medicament from the pump. The inlet pressure sensor is positioned along the inlet fluid path and configured to measure inlet fluid pressure. The outlet pressure sensor is positioned along the outlet fluid path and configured to measure outlet fluid pressure. The controller is workingly coupled with the inlet pressure sensor, the outlet pressure sensor, and the drive component, wherein the controller is configured to adjust at least one parameter of the drive component based on input information received from the inlet pressure sensor and/or the outlet pressure sensor.

公开(公告)号：US20210146055A1

公开(公告)日：2021-05-20

申请号：US17094176

申请日：2020-11-10

Applicant: AMGEN INC.

Inventor： Mehran Mojarrad ,  Ali Nekouzadeh ,  Susan McConnell Montalvo ,  Scott R. Gibson ,  Sheldon B. Moberg ,  Joshua Tamsky ,  Paul D. Faucher

IPC: A61M5/315

Abstract: Drug delivery devices are configured to include a gas-driven piston assembly having a flexible pushrod, a non-linear guide include a non-linear guide pathway at least partially surrounding the flexible pushrod, a cylinder at least partially surrounding the flexible pushrod, and a piston movable within the cylinder in response to the pressurized gas entering the cylinder. Some arrangements include a roller pushrod guide system and/or a gear pushrod guide system.

公开(公告)号：US20220387702A1

公开(公告)日：2022-12-08

申请号：US17770331

申请日：2020-10-23

Applicant: AMGEN INC.

Inventor： Scott R. Gibson ,  Mehran Mojarrad ,  Paul D. Faucher

IPC: A61M5/142 ,  A61M5/168

Abstract: A drug delivery device is provided that includes a housing, a fluid displacement assembly at least partially supported by and/or surrounded by the housing, and a drive component at least partially supported by and/or surrounded by the housing. The fluid displacement assembly includes a ring tube portion. The drive component includes an eccentric component having a contact surface configured to directly or indirectly apply a compression force to a compression patch of the ring tube portion such that when the eccentric component rotates about an axis, the contact surface moves along generally circular path and drives the medicament through the fluid displacement assembly. The compression force between the contact surface and the ring tube portion is preferably substantially constant throughout a complete revolution about the axis by the eccentric component.