公开(公告)号：US20130071387A1

公开(公告)日：2013-03-21

申请号：US13678407

申请日：2012-11-15

Applicant: AMGEN INC.

Inventor： Tiansheng LI ,  Christopher James Sloey

IPC: A61K47/10

CPC classification number: A61K47/10 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/1816 ,  A61K38/193 ,  A61K39/39533 ,  A61K39/39591 ,  A61K47/02 ,  A61K47/18 ,  A61K47/183 ,  A61K47/186 ,  A61K47/26 ,  A61K2039/505

Abstract: A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte.

Abstract translation: 本文公开了稳定水性蛋白质或抗体制剂的方法。 此外，涵盖稳定的药物制剂，其包含生物活性蛋白质，去稳定浓度的防腐剂和稳定的渗透液浓度。

公开(公告)号：US20210069334A1

公开(公告)日：2021-03-11

申请号：US16855896

申请日：2020-04-22

Applicant: Amgen Inc.

Inventor： Tiansheng LI ,  Christopher James SLOEY

IPC: A61K47/10 ,  A61K39/395 ,  A61K9/00 ,  A61K9/19 ,  A61K38/18 ,  A61K38/19 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26

Abstract: A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte.