公开(公告)号：US11919953B2

公开(公告)日：2024-03-05

申请号：US17375958

申请日：2021-07-14

Applicant: AMGEN INC.

Inventor： Sue J. Sohn ,  Marissa Mock ,  Ian Nevin Foltz ,  Agnieszka Kielczewska ,  Kathy Manchulenko ,  Yannick Bulliard ,  Xiaoshan Min

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

CPC classification number: C07K16/2803 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: Provided herein are TIGIT binding proteins, CD112R binding proteins, and combinations thereof. Also provided are compositions comprising TIGIT binding proteins and CD112R binding proteins, optionally further comprising PD-1 binding proteins. Related conjugates, fusion proteins, nucleic acids, vectors, host cells and kits are additionally provided. Further provided are pharmaceutical compositions comprising a TIGIT binding protein, CD112R binding protein, or a combination thereof, optionally, further comprising a PD-1 antigen binding protein, or a conjugate, fusion protein, nucleic acid, vector, or host cell, and a pharmaceutically acceptable carrier, diluent, or excipient, and methods of treating subjects in need thereof.