公开(公告)号：US11780914B2

公开(公告)日：2023-10-10

申请号：US17031674

申请日：2020-09-24

Applicant: AMGEN INC.

Inventor： Agnes E. Hamburger ,  Cen Xu ,  Hong Sun ,  Yuan D. Shih ,  Dohan Weeraratne

IPC: A61K39/395 ,  C07K16/26 ,  C12N15/13 ,  A61P25/06 ,  C07K16/42 ,  A61K39/00 ,  A61K9/00

CPC classification number: C07K16/26 ,  A61P25/06 ,  C07K16/4283 ,  A61K9/0019 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76

Abstract: The present invention relates to monoclonal antibodies that specifically bind to human pituitary adenylate cyclase activating polypeptide (PACAP) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the monoclonal antibodies are also described.

公开(公告)号：US10822408B2

公开(公告)日：2020-11-03

申请号：US16063152

申请日：2016-12-15

Applicant: AMGEN INC.

Inventor： Agnes E. Hamburger ,  Cen Xu ,  Hong Sun ,  Yuan D. Shih ,  Dohan Weeraratne

IPC: A61K39/395 ,  C07K16/26 ,  A61P25/06 ,  C07K16/42 ,  A61K39/00 ,  A61K9/00

Abstract: The present invention relates to monoclonal antibodies that specifically bind to human pituitary adenylate cyclase activating polypeptide (PACAP) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the monoclonal antibodies are also described.