公开(公告)号：US20140080783A1

公开(公告)日：2014-03-20

申请号：US14082681

申请日：2013-11-18

申请人： ARDEA BIOSCIENCES, INC.

发明人： Mark CHAPMAN

IPC分类号： A61K31/18 ,  A61K31/5377 ,  A61K31/7068 ,  A61N5/00 ,  A61K31/4188 ,  A61K31/436 ,  A61K45/06 ,  A61K31/517 ,  A61K31/185

CPC分类号： A61K31/18 ,  A61K31/185 ,  A61K31/4188 ,  A61K31/436 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/7064 ,  A61K31/7068 ,  A61K45/06 ,  A61N5/00 ,  A61K2300/00

摘要： The present invention relates to the field of oncology and provides compositions and methods for treating specific cancers, including non small cell lung cancer, breast cancer, thyroid cancer, pancreatic cancer, colon cancer, melanoma, hepatoma and adenocarcinoma. Particularly, compositions and methods involving administration, either simultaneously or sequentially, of pharmaceutical combinations comprising (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide with other compounds, to patients suffering from cancer are described.

摘要翻译： 本发明涉及肿瘤学领域，并提供用于治疗特定癌症的组合物和方法，包括非小细胞肺癌，乳腺癌，甲状腺癌，胰腺癌，结肠癌，黑素瘤，肝癌和腺癌。 特别地，包括同时或依次施用包含（S）-N-（3,4-二氟-2-（2-氟-4-碘苯基氨基）-6-甲氧基苯基）-1-（ 2,3-二羟基丙基）环丙烷-1-磺酰胺与其他化合物对患有癌症的患者进行了描述。