公开(公告)号：US10119960B2

公开(公告)日：2018-11-06

申请号：US15316710

申请日：2015-06-09

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Junseok Chae ,  Jennie Appel ,  Joseph Liao

IPC: G01N33/50 ,  G01N21/84 ,  G01N33/487 ,  G01N33/574

Abstract: Systems and methods for performing cancer screening assays are disclosed. The disclosed systems and methods use a thin film comprising cross-linked polysiloxane. At least a portion of a biological sample to be assayed is contacted with the thin film, along with a cell culture media. After a subsequent incubation period, the thin film is visualized to detect a wrinkle pattern (or lack thereof). The presence of one or more wrinkles and/or a higher degree of wrinkling in the thin film indicates the presence of cancer cells in the biological sample. The disclosed systems and methods can be incorporated into improved assays and kits for cancer screening.

公开(公告)号：US20170191989A1

公开(公告)日：2017-07-06

申请号：US15316710

申请日：2015-06-09

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Junseok Chae ,  Jennie Appel ,  Joseph Liao

IPC: G01N33/50 ,  G01N21/84 ,  G01N33/487

CPC classification number: G01N33/5091 ,  G01N21/8422 ,  G01N33/487 ,  G01N33/574

Abstract: Systems and methods for performing cancer screening assays are disclosed. The disclosed systems and methods use a thin film comprising cross-linked polysiloxane. At least a portion of a biological sample to be assayed is contacted with the thin film, along with a cell culture media. After a subsequent incubation period, the thin film is visualized to detect a wrinkle pattern (or lack thereof). The presence of one or more wrinkles and/or a higher degree of wrinkling in the thin film indicates the presence of cancer cells in the biological sample. The disclosed systems and methods can be incorporated into improved assays and kits for cancer screening.