公开(公告)号：US4443433A

公开(公告)日：1984-04-17

申请号：US438104

申请日：1982-11-01

申请人： Adolph Knecht ,  Michael Schneider ,  Walter Ambrosch

发明人： Adolph Knecht ,  Michael Schneider ,  Walter Ambrosch

IPC分类号： A61K33/08 ,  C01F7/34 ,  C01D5/10

CPC分类号： C01F7/34 ,  A61K33/08

摘要： The present invention provides a process for the preparation of an antacid material based upon magnesium aluminium hydroxide, wherein magnesium hydroxide and/or magnesium oxide is reacted in an atomic ratio of magnesium to aluminium of 1:1 to 3:1 with an aqueous solution of aluminium sulphate until the pH of the reaction mixture is from 4.0 to 8.0, whereafter water-soluble components are removed from the mixture in a known manner and the mixture is isolated and, if desired, dried or preferably the mixture obtained after centrifuging or filtering off is used without further purification and optionally dried.The present invention also provides pharmaceutical compositions containing an antacid material prepared by these processes, in admixture with a conventional pharmaceutical adjuvant.Furthermore, the present invention provides a method of combating hyperacidity and gastrointestinal diseases, which comprises administering an antacid material prepared by the above processes.

摘要翻译： 本发明提供了一种制备基于氢氧化铝的抗酸剂材料的方法，其中氢氧化镁和/或氧化镁以1：1至3：1的原子比与镁与铝的原子比与 硫酸铝，直到反应混合物的pH为4.0至8.0，然后以已知方式从混合物中除去水溶性组分，并分离混合物，如果需要，干燥或优选在离心或过滤后获得的混合物 无需进一步纯化即可使用，任选地干燥。 本发明还提供含有通过这些方法制备的抗酸剂材料的药物组合物，与常规药物佐剂混合。 此外，本发明提供了一种抗胃酸和胃肠疾病的方法，其包括施用通过上述方法制备的抗酸剂材料。