公开(公告)号：US09957270B2

公开(公告)日：2018-05-01

申请号：US15124654

申请日：2015-03-13

Applicant: Agency for Science, Technology and Research

Inventor： Haishan Wang ,  Dizhong Chen ,  Chang Kai Soh

IPC: A01N43/90 ,  A61K31/52 ,  A61K31/519 ,  C07D473/00 ,  C07D487/00 ,  C07D473/34 ,  C07D473/32 ,  A61K45/06 ,  A61K31/5377 ,  C07D473/16 ,  C07D473/40

CPC classification number: C07D473/34 ,  A61K31/52 ,  A61K31/5377 ,  A61K45/06 ,  C07D473/16 ,  C07D473/32 ,  C07D473/40 ,  A61K2300/00

Abstract: The present invention relates to fused pyrimidine-based hydroxamate compounds of formula (I), comprising a hydroxamate group, that are inhibitors of histone deacetylase (HDAC) and kinases. More particularly, the present invention relates to hydroxamate substituted purine or 5H-pyrrolo[3,2-d]pyrimidine derivatives, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having histone deacetylase, non-histone deacetylase and kinase activities/functions and/or via unspecified/multi-targeted mechanisms.

公开(公告)号：US20180265512A1

公开(公告)日：2018-09-20

申请号：US15916986

申请日：2018-03-09

Applicant: Agency for Science, Technology and Research

Inventor： Haishan Wang ,  Dizhong Chen ,  Chang Kai Soh

IPC: C07D473/34 ,  A61K31/52 ,  C07D473/40 ,  A61K45/06 ,  A61K31/5377 ,  C07D473/32 ,  C07D473/16

CPC classification number: C07D473/34 ,  A61K31/52 ,  A61K31/5377 ,  A61K45/06 ,  C07D473/16 ,  C07D473/32 ,  C07D473/40 ,  A61K2300/00

Abstract: The present invention relates to fused pyrimidine-based hydroxamate compounds of formula (I), comprising a hydroxamate group, that are inhibitors of hiStone deacetylase (HDAC) and kinases. More particularly, the present invention relates to hydroxamate substituted purine or 5H-pyrrolo[3,2-d]pyrimidine derivatives, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having histone deacetylase, non-histone deacetylase and kinase activities/functions and/or via unspecified/multi-targeted mechanisms.