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公开(公告)号：US5977078A
公开(公告)日：1999-11-02
申请号：US934450
申请日：1997-09-19
CPC分类号： A61K31/6615 , A61K31/683 , C07F9/117 , Y10S514/851
摘要： The present invention provides compositions that are cell permeable antagonists of inositol polyphosphates. In addition, the invention provides methods for enhancing chloride ion secretion from a cell by contacting the cells with cell permeable antagonists of inositol polyphosphates. The invention also provides methods for enhancing chloride ion secretion in an individual by administering cell permeable antagonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with cystic fibrosis in an individual by administering a cell permeable antagonist of inositol polyphosphates to the individual. The invention also provides compositions that are cell permeable agonists of inositol polyphosphates. In addition, the invention provides methods for decreasing chloride ion secretion from a cell by contacting the cell with cell permeable agonists of inositol polyphosphates. The invention also provides methods for decreasing chloride ion secretion in an individual by administering cell permeable agonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with secretory diarrhea in an individual by administering cell permeable agonists of inositol polyphosphates to the individual.
摘要翻译： 本发明提供了作为肌醇多磷酸盐的细胞渗透性拮抗剂的组合物。 此外，本发明提供了通过使细胞与肌醇多磷酸盐的细胞可渗透的拮抗剂接触来提高细胞中氯离子分泌的方法。 本发明还提供了通过向个体施用肌醇多磷酸盐的细胞可渗透的拮抗剂来增强个体中的氯离子分泌的方法。 本发明还提供了通过向个体施用肌醇多磷酸盐的细胞可渗透拮抗剂来减轻个体中与囊性纤维化相关的征兆或症状的方法。 本发明还提供了作为肌醇多磷酸盐的细胞渗透性激动剂的组合物。 此外，本发明提供了通过使细胞与肌醇多磷酸盐的细胞可渗透的激动剂接触来减少细胞的氯离子分泌的方法。 本发明还提供通过向个体施用肌醇多磷酸盐的细胞可渗透的激动剂来减少个体中的氯离子分泌的方法。 本发明另外提供了通过向个体施用肌醇多磷酸盐的细胞可渗透的激动剂来减轻个体中与分泌性腹泻相关的征兆或症状的方法。
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公开(公告)号：US5880099A
公开(公告)日：1999-03-09
申请号：US926831
申请日：1997-09-10
CPC分类号： A61K31/6615 , A61K31/683 , C07F9/117 , Y10S514/851
摘要： The present invention provides compositions that are cell permeable antagonists of inositol polyphosphates. In addition, the invention provides methods for enhancing chloride ion secretion from a cell by contacting the cells with cell permeable antagonists of inositol polyphosphates. The invention also provides methods for enhancing chloride ion secretion in an individual by administering cell permeable antagonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with cystic fibrosis in an individual by administering a cell permeable antagonist of inositol polyphosphates to the individual. The invention also provides compositions that are cell permeable agonists of inositol polyphosphates. In addition, the invention provides methods for decreasing chloride ion secretion from a cell by contacting the cell with cell permeable agonists of inositol polyphosphates. The invention also provides methods for decreasing chloride ion secretion in an individual by administering cell permeable agonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with secretory diarrhea in an individual by administering cell permeable agonists of inositol polyphosphates to the individual.
摘要翻译： 本发明提供了作为肌醇多磷酸盐的细胞渗透性拮抗剂的组合物。 此外，本发明提供了通过使细胞与肌醇多磷酸盐的细胞可渗透的拮抗剂接触来提高细胞中氯离子分泌的方法。 本发明还提供了通过向个体施用肌醇多磷酸盐的细胞可渗透的拮抗剂来增强个体中的氯离子分泌的方法。 本发明还提供了通过向个体施用肌醇多磷酸盐的细胞可渗透拮抗剂来减轻个体中与囊性纤维化相关的征兆或症状的方法。 本发明还提供了作为肌醇多磷酸盐的细胞渗透性激动剂的组合物。 此外，本发明提供了通过使细胞与肌醇多磷酸盐的细胞可渗透的激动剂接触来减少细胞中氯离子分泌的方法。 本发明还提供通过向个体施用肌醇多磷酸盐的细胞可渗透的激动剂来减少个体中的氯离子分泌的方法。 本发明另外提供了通过向个体施用肌醇多磷酸盐的细胞可渗透的激动剂来减轻个体中与分泌性腹泻相关的征兆或症状的方法。
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3.发明授权Method to refresh the ink in nozzles of an inkjet print head in an inkjet printing apparatus 有权在喷墨打印装置中刷新喷墨打印头的喷嘴中的油墨的方法公开(公告)号：US08485635B2
公开(公告)日：2013-07-16
申请号：US13114528
申请日：2011-05-24
申请人： Christoph Stadler
发明人： Christoph Stadler
IPC分类号： B41J2/165
CPC分类号： B41J2/16526 , B41J2/1714
摘要： In a method to regenerate during operation ink in nozzles of at least one inkjet print head operating according to drop on demand in an inkjet print apparatus, nozzles of the print head that generate print dots on a printing substrate are activated such that the nozzles output first ink droplets of a predetermined volume in a direction towards the printing substrate. Nozzles that are not being currently used to generate print dots on the printing substrate are activated such that they output at least one second ink droplet of a smaller volume in comparison to the first ink droplets volume. During at least the outputting of the second ink droplet, a suction flow is generated between the inkjet print head and the printing substrate of such strength that the second ink droplet is deflected so it does not arrive at the printing substrate.
摘要翻译： 在喷墨打印设备中按照要求按照要求操作的至少一个喷墨打印头的喷嘴中的油墨中进行再生的方法中，在打印基板上产生打印点的打印头的喷嘴被激活，使得喷嘴首先输出 在朝向打印基板的方向上具有预定体积的墨滴。 目前不用于在印刷基板上产生印刷点的喷嘴被激活，使得它们与第一墨滴体积相比输出更小体积的至少一个第二墨滴。 在至少输出第二墨滴期间，在喷墨打印头和打印基底之间产生吸力，其强度使得第二墨滴偏转，使得其不会到达打印基底。
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4.发明申请METHOD TO REFRESH THE INK IN NOZZLES OF AN INKJET PRINT HEAD IN AN INKJET PRINTING APPARATUS 有权喷墨打印机中喷墨打印头的喷嘴中的墨水冲洗方法公开(公告)号：US20120033016A1
公开(公告)日：2012-02-09
申请号：US13114528
申请日：2011-05-24
申请人： Christoph Stadler
发明人： Christoph Stadler
IPC分类号： B41J2/04
CPC分类号： B41J2/16526 , B41J2/1714
摘要： In a method to regenerate during operation ink in nozzles of at least one inkjet print head operating according to drop on demand in an inkjet print apparatus, nozzles of the print head that generate print dots on a printing substrate are activated such that the nozzles output first ink droplets of a predetermined volume in a direction towards the printing substrate. Nozzles that are not being currently used to generate print dots on the printing substrate are activated such that they output at least one second ink droplet of a smaller volume in comparison to the first ink droplets volume. During at least the outputting of the second ink droplet, a suction flow is generated between the inkjet print head and the printing substrate of such strength that the second ink droplet is deflected so it does not arrive at the printing substrate.
摘要翻译： 在喷墨打印设备中按照要求按照要求操作的至少一个喷墨打印头的喷嘴中的油墨中进行再生的方法中，在打印基板上产生打印点的打印头的喷嘴被激活，使得喷嘴首先输出 在朝向打印基板的方向上具有预定体积的墨滴。 目前不用于在印刷基板上产生印刷点的喷嘴被激活，使得它们与第一墨滴体积相比输出更小体积的至少一个第二墨滴。 在至少输出第二墨滴期间，在喷墨打印头和打印基底之间产生吸力，其强度使得第二墨滴偏转，使得其不会到达打印基底。
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