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公开(公告)号:US20130053362A1
公开(公告)日:2013-02-28
申请号:US13552516
申请日:2012-07-18
申请人: Alfredo C. CASTRO , Catherine A. EVANS , Somarajannair JANARDANANNAIR , Andre LESCARBEAU , Tao LIU , Daniel A. SNYDER , Martin R. TREMBLAY , Pingda REN , Yi LIU , Liansheng LI , Katrina CHAN
发明人: Alfredo C. CASTRO , Catherine A. EVANS , Somarajannair JANARDANANNAIR , Andre LESCARBEAU , Tao LIU , Daniel A. SNYDER , Martin R. TREMBLAY , Pingda REN , Yi LIU , Liansheng LI , Katrina CHAN
IPC分类号: A61K31/506 , C07D401/12 , C07D471/04 , C07D403/12 , A61K31/517 , A61P37/00 , C07D417/14 , C07D413/14 , C07D405/14 , A61K31/5377 , A61P35/00 , A61P29/00 , C07D401/14 , C07D403/14
CPC分类号: C07D401/14 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D411/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , C12N9/1205 , C12Y207/01137 , Y02A50/414
摘要: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein.
摘要翻译: 本文描述了调节激酶活性(包括PI3激酶活性)的化合物和药物组合物,以及化合物,药物组合物和治疗与激酶活性(包括P13激酶活性)相关的疾病和病症的方法。
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公开(公告)号:US20150322797A1
公开(公告)日:2015-11-12
申请号:US14694435
申请日:2015-04-23
申请人: Daniel A. SNYDER , Lane Thornton , Alex J. Simpson
发明人: Daniel A. SNYDER , Lane Thornton , Alex J. Simpson
IPC分类号: F01D5/16
CPC分类号: F01D5/16 , F01D5/187 , F05D2260/96 , Y10T29/49337
摘要: A blade element and methods of manufacturing blade elements are provided for blade elements of a gas turbine engine. In one embodiment, a blade element includes a first inner surface of the blade element, wherein the first inner surface is associated with a first outer blade surface of the blade element, and a second inner surface of the blade element, wherein the second inner surface is associated with a second outer blade surface of the blade element and wherein the second inner surface is opposite from the first inner surface. The blade element may also include a cross-tie configured to connect the first inner surface to the second inner surface, wherein the cross-tie is positioned along a trailing edge of the blade element and the cross-tie is configured to reduce vibration mode effects of the blade element.
摘要翻译: 叶片元件和制造叶片元件的方法被设置用于燃气涡轮发动机的叶片元件。 在一个实施例中,叶片元件包括叶片元件的第一内表面,其中第一内表面与叶片元件的第一外叶表面和叶片元件的第二内表面相关联,其中第二内表面 与叶片元件的第二外叶片表面相关联,并且其中第二内表面与第一内表面相对。 刀片元件还可以包括被配置为将第一内表面连接到第二内表面的交叉连接,其中交叉连接沿刀片元件的后缘定位,并且交叉连接被配置为减少振动模式效应 的刀片元件。
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